Hepatic lipase activity is lower in african american men than in white american men: Effects of 5' flanking polymorphism in the hepatic lipase gene (LIPC)

Gloria Lena Vega, Luther T. Clark, Aylmer Tang, Santica Marcovina, Scott M. Grundy, Jonathan C. Cohen

Research output: Contribution to journalArticle

140 Scopus citations

Abstract

Plasma high density lipoprotein cholesterol (HDL-C) concentrations are higher in African American men than in white men, but the mechanism(s) responsible for this ethnic difference has not been elucidated. This study examined the relationship between hepatic lipase activity, plasma HDL-C concentrations, and a hepatic lipase polymorphism (-514T) in African American and white American men. Consistent with previous reports, plasma HDL-C concentrations were significantly higher in African American men than in white American men. Mean post-heparin plasma hepatic lipase activity was significantly lower in African American than in white American men (27 ± 12 vs. 44 ± 17 mmol · h-1 · 1-1, P < 0.001). The -514T hepatic lipase allele was associated with low hepatic lipase activity in both populations, and was 3-fold more common among African Americans than white Americans. Taken together, these data suggest that genetic differences in hepatic lipase activity contribute to the differences in plasma HDL-C concentrations between African American men and white American men.

Original languageEnglish (US)
Pages (from-to)228-232
Number of pages5
JournalJournal of lipid research
Volume39
Issue number1
StatePublished - Jan 1998

Keywords

  • High density lipoprotein cholesterol

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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