Hepatic lipase (LIPC) promoter polymorphism in men with coronary artery disease

Allele frequency and effects on hepatic lipase activity and plasma HDL-C concentrations

Ralph V. Shohet, Gloria L Vega, Azam Anwar, Joaquin E. Cigarroa, Scott M Grundy, Jonathan C Cohen

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49 Citations (Scopus)

Abstract

Hepatic lipase is an important determinant of plasma HDL concentration and LDL subclass distribution and may therefore influence susceptibility to coronary artery disease (CAD). To assess the effect of genetic variation in hepatic lipase activity on CAD susceptibility, we determined the frequency of the -514T allele of hepatic lipase in white men with CAD and in controls who did not have CAD. In men with CAD, postheparin plasma hepatic lipase activity was 15% to 20% lower in heterozygotes and 30% lower in homozygotes for the - 514T allele. Allele frequencies were similar in cases and controls, however, and were consistent with Hardy-Weinberg expectation in both groups. This finding was confirmed in a second group comprising cases with premature symptomatic CAD and controls who were free of disease. These data indicate that a primary decrease in hepatic lipase activity of as much as 30% does not influence susceptibility to CAD in white men.

Original languageEnglish (US)
Pages (from-to)1975-1978
Number of pages4
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume19
Issue number8
StatePublished - Aug 1999

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Lipase
Gene Frequency
Coronary Artery Disease
Liver
Disease Susceptibility
Homozygote
Heterozygote
Alleles

Keywords

  • Atherosclerosis
  • HDL
  • Hepatic lipase
  • Polymorphism
  • Risk factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Hepatic lipase (LIPC) promoter polymorphism in men with coronary artery disease: Allele frequency and effects on hepatic lipase activity and plasma HDL-C concentrations",
abstract = "Hepatic lipase is an important determinant of plasma HDL concentration and LDL subclass distribution and may therefore influence susceptibility to coronary artery disease (CAD). To assess the effect of genetic variation in hepatic lipase activity on CAD susceptibility, we determined the frequency of the -514T allele of hepatic lipase in white men with CAD and in controls who did not have CAD. In men with CAD, postheparin plasma hepatic lipase activity was 15{\%} to 20{\%} lower in heterozygotes and 30{\%} lower in homozygotes for the - 514T allele. Allele frequencies were similar in cases and controls, however, and were consistent with Hardy-Weinberg expectation in both groups. This finding was confirmed in a second group comprising cases with premature symptomatic CAD and controls who were free of disease. These data indicate that a primary decrease in hepatic lipase activity of as much as 30{\%} does not influence susceptibility to CAD in white men.",
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AU - Anwar, Azam

AU - Cigarroa, Joaquin E.

AU - Grundy, Scott M

AU - Cohen, Jonathan C

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N2 - Hepatic lipase is an important determinant of plasma HDL concentration and LDL subclass distribution and may therefore influence susceptibility to coronary artery disease (CAD). To assess the effect of genetic variation in hepatic lipase activity on CAD susceptibility, we determined the frequency of the -514T allele of hepatic lipase in white men with CAD and in controls who did not have CAD. In men with CAD, postheparin plasma hepatic lipase activity was 15% to 20% lower in heterozygotes and 30% lower in homozygotes for the - 514T allele. Allele frequencies were similar in cases and controls, however, and were consistent with Hardy-Weinberg expectation in both groups. This finding was confirmed in a second group comprising cases with premature symptomatic CAD and controls who were free of disease. These data indicate that a primary decrease in hepatic lipase activity of as much as 30% does not influence susceptibility to CAD in white men.

AB - Hepatic lipase is an important determinant of plasma HDL concentration and LDL subclass distribution and may therefore influence susceptibility to coronary artery disease (CAD). To assess the effect of genetic variation in hepatic lipase activity on CAD susceptibility, we determined the frequency of the -514T allele of hepatic lipase in white men with CAD and in controls who did not have CAD. In men with CAD, postheparin plasma hepatic lipase activity was 15% to 20% lower in heterozygotes and 30% lower in homozygotes for the - 514T allele. Allele frequencies were similar in cases and controls, however, and were consistent with Hardy-Weinberg expectation in both groups. This finding was confirmed in a second group comprising cases with premature symptomatic CAD and controls who were free of disease. These data indicate that a primary decrease in hepatic lipase activity of as much as 30% does not influence susceptibility to CAD in white men.

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KW - Risk factor

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