Hepatitis B virus genotype G: Prevalence and impact in patients co-infected with human immunodeficiency virus

Doan Y. Dao, Jody Balko, Nahid Attar, Enayet Neak, He Jun Yuan, William M. Lee, Mamta K. Jain

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Relatively little is known about the role of hepatitis B virus (HBV) genotype G (HBV/G) in patients co-infected with human immunodeficiency virus (HIV) and HBV. This study examined the prevalence and association of HBV/G to liver fibrosis in co-infected patients. HBV genotypes were determined by direct sequencing of the HBV surface gene or Trugene® HBV 1.0 assay in 133 patients infected with HIV/HBV. Quantitative testing of HBV-DNA, HBeAg, and anti-HBe were performed using the Versant® HBV 3.0 (for DNA) and the ADVIA®Centaur assay. The non-invasive biomarkers Fib-4 and APRI were used to assess fibrosis stage. Genotype A was present in 103/133 (77%) of the cohort, genotype G in 18/133 (14%) with genotypes D in 8/133, (6%), F 2/133 (1.5%), and H 2/133 (1.5%). Genotype G was associated with hepatitis B e antigen-positivity and high HBV-DNA levels. Additionally, HBV/G (OR 8.25, 95% CI 2.3-29.6, P=0.0012) was associated with advanced fibrosis score using Fib-4, whereas, being black was not (OR 0.19, 95% CI 0.05-0.07, P=0.01). HBV/G in this population exhibited a different phenotype than expected for pure G genotypes raising the question of recombination or mixed infections. The frequent finding of HBV/G in co-infected patients and its association with more advanced fibrosis, suggests that this genotype leads to more rapid liver disease progression. Further studies are needed to understand why this genotype occurs more frequently and what impact it has on liver disease progression in patients with HBV/HIV.

Original languageEnglish (US)
Pages (from-to)1551-1558
Number of pages8
JournalJournal of Medical Virology
Volume83
Issue number9
DOIs
StatePublished - Sep 1 2011

Keywords

  • APRI
  • Fib-4
  • Fibrosis
  • HBV genotype
  • HIV

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Hepatitis B virus genotype G: Prevalence and impact in patients co-infected with human immunodeficiency virus'. Together they form a unique fingerprint.

Cite this