Hepatitis C genotype influences post-liver transplant outcomes

Isabel Campos-Varela, Jennifer C. Lai, Elizabeth C. Verna, Jacqueline G. O'Leary, R. Todd Stravitz, Lisa M. Forman, James F. Trotter, Robert S. Brown, Norah A. Terrault

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

In nontransplant patients with chronic hepatitis C virus (HCV), HCV genotype has been linked with a differential response to antiviral therapy, risk of steatosis and fibrosis, as well as all-cause mortality, but the role of HCV genotypes in posttransplant disease progression is less clear. Methods. Using the multicenter CRUSH-C cohort, genotype-specific rates of advanced fibrosis, HCV-specific graft loss and response of antiviral therapy were examined. Results. Among 745 recipients (605 [81%] genotype 1, 53 [7%] genotype 2, and 87 [12%] genotype 3), followed for a median of 3.1 years (range, 2.0-8.0), the unadjusted cumulative rate of advanced fibrosis at 3 years was 31%, 19%, and 19% for genotypes 1, 2, and 3 (P = 0.008). After multivariable adjustment, genotype remained a significant predictor, with genotype 2 having a 66% lower risk (P = 0.02) and genotype 3 having a 41% lower risk (P = 0.07) of advanced fibrosis compared to genotype 1 patients. The cumulative 5-year rates of HCV-specific graft survival were 84%, 90%, and 94% for genotypes 1, 2, and 3 (P = 0.10). A total of 37% received antiviral therapy, with higher rates of sustained virologic response in patients with genotype 2 (hazard ratios, 5.10; P = 0.003) and genotype 3 (hazard ratios, 3.27; P = 0.006) compared to patients with genotype 1. Conclusion. Risk of advanced fibrosis and response to therapy are strongly influenced by genotype. Liver transplantation recipients with HCV genotype 1 have the highest risk of advanced fibrosis and lowest sustained virologic response rate. These findings highlight the need for genotype-specific management strategies.

Original languageEnglish (US)
Pages (from-to)835-840
Number of pages6
JournalTransplantation
Volume99
Issue number4
DOIs
StatePublished - Apr 1 2015

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Hepatitis C genotype influences post-liver transplant outcomes'. Together they form a unique fingerprint.

  • Cite this

    Campos-Varela, I., Lai, J. C., Verna, E. C., O'Leary, J. G., Todd Stravitz, R., Forman, L. M., Trotter, J. F., Brown, R. S., & Terrault, N. A. (2015). Hepatitis C genotype influences post-liver transplant outcomes. Transplantation, 99(4), 835-840. https://doi.org/10.1097/TP.0000000000000413