Hepatitis C virus

A new class of virus associated with particles derived from very low-density lipoproteins

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) infects 3% of the world population and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral particles are integral to very low-density lipoprotein (VLDL)-derived lipoprotein particles. The virus is assembled into VLDL in hepatocytes and released out of the cells together with VLDL. The virus then infects more hepatocytes by entering the cells through the low-density lipoprotein receptor, which mediates uptake of majorities of VLDL-derived lipoprotein particles. These observations suggest that HCV may belong to a novel class of viruses that is associated with VLDL. Understanding the relationship between HCV and VLDL metabolism may reveal new strategies to treat HCV infection.

Original languageEnglish (US)
Pages (from-to)1099-1103
Number of pages5
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume32
Issue number5
DOIs
StatePublished - May 2012

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VLDL Lipoproteins
Hepacivirus
Viruses
Lipoproteins
Hepatocytes
LDL Receptors
Liver Failure
Virus Diseases
Virion
Population

Keywords

  • Hepatitis C virus
  • Lipoproteins
  • Viruses

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Hepatitis C virus: A new class of virus associated with particles derived from very low-density lipoproteins",
abstract = "Hepatitis C virus (HCV) infects 3{\%} of the world population and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral particles are integral to very low-density lipoprotein (VLDL)-derived lipoprotein particles. The virus is assembled into VLDL in hepatocytes and released out of the cells together with VLDL. The virus then infects more hepatocytes by entering the cells through the low-density lipoprotein receptor, which mediates uptake of majorities of VLDL-derived lipoprotein particles. These observations suggest that HCV may belong to a novel class of viruses that is associated with VLDL. Understanding the relationship between HCV and VLDL metabolism may reveal new strategies to treat HCV infection.",
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AB - Hepatitis C virus (HCV) infects 3% of the world population and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral particles are integral to very low-density lipoprotein (VLDL)-derived lipoprotein particles. The virus is assembled into VLDL in hepatocytes and released out of the cells together with VLDL. The virus then infects more hepatocytes by entering the cells through the low-density lipoprotein receptor, which mediates uptake of majorities of VLDL-derived lipoprotein particles. These observations suggest that HCV may belong to a novel class of viruses that is associated with VLDL. Understanding the relationship between HCV and VLDL metabolism may reveal new strategies to treat HCV infection.

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