Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis: Prospective diagnosis with MR imaging and explantation correlation

G. A. Krinsky, V. S. Lee, N. D. Theise, J. C. Weinreb, N. M. Rofsky, T. Diflo, L. W. Teperman

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To determine the sensitivity and specificity of magnetic resonance (MR) imaging for detection of hepatocellular carcinoma (HCC) and dysplastic nodules (DNs) by using explantation correlation in patients with cirrhosis and no known HCC: MATERIALS AND METHODS: Seventy-one patients without a known history of HCC Who underwent MR imaging and subsequent transplantation within 90 days Were examined, Breath-hold turbo short inversion time inversion-recovery and/or T2-weighted turbo spin-echo MR images were obtained. Dynamic two- or three-dimensional gadolinium-enhanced gradient-echo MR images were obtained in the hepatic arterial, portal venous, and equilibrium phases. Prospective MR image interpretations were compared directly with explanted liver pathologic results. RESULTS: Eleven (15%) of 71 patients had hepatic malignancies; MR imaging enabled diagnosis of tumor in six (54%) of 11 patients. On a lesion-by-lesion basis, MR imaging depicted 11 of 20 hepatic neoplasms, for an overall sensitivity of 55%. MR imaging depicted four (80%) of five lesions larger than 2 cm, six (50%) of 12 lesions 1-2 cm, and one (33%) of three lesions smaller than 1 cm. MR imaging depicted only nine (15%) of 59 DNs. The specificities of MR imaging for detection of HCC and DNs on a per patient basis were 60 (86%) of 70 patients and 53(85%) of 62 patients, respectively. CONCLUSION: MR imaging is insensitive for the diagnosis of small (<2-cm) HCCs and DNs.

Original languageEnglish (US)
Pages (from-to)445-454
Number of pages10
JournalRadiology
Volume219
Issue number2
StatePublished - 2001

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Hepatocellular Carcinoma
Fibrosis
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Liver
Gadolinium
Liver Neoplasms
Neoplasms
Transplantation
Sensitivity and Specificity

Keywords

  • Liver neoplasms, 761.31, 761.321 761.323
  • Liver neoplasms, MR, 761.1 21411 761.121412, 761.121413, 761.121415, 761.12143
  • Liver, cirrhosis, 761.794
  • Liver, nodules, 761.3198
  • Liver, transplantation, 761.459

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Krinsky, G. A., Lee, V. S., Theise, N. D., Weinreb, J. C., Rofsky, N. M., Diflo, T., & Teperman, L. W. (2001). Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis: Prospective diagnosis with MR imaging and explantation correlation. Radiology, 219(2), 445-454.

Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis : Prospective diagnosis with MR imaging and explantation correlation. / Krinsky, G. A.; Lee, V. S.; Theise, N. D.; Weinreb, J. C.; Rofsky, N. M.; Diflo, T.; Teperman, L. W.

In: Radiology, Vol. 219, No. 2, 2001, p. 445-454.

Research output: Contribution to journalArticle

Krinsky, GA, Lee, VS, Theise, ND, Weinreb, JC, Rofsky, NM, Diflo, T & Teperman, LW 2001, 'Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis: Prospective diagnosis with MR imaging and explantation correlation', Radiology, vol. 219, no. 2, pp. 445-454.
Krinsky, G. A. ; Lee, V. S. ; Theise, N. D. ; Weinreb, J. C. ; Rofsky, N. M. ; Diflo, T. ; Teperman, L. W. / Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis : Prospective diagnosis with MR imaging and explantation correlation. In: Radiology. 2001 ; Vol. 219, No. 2. pp. 445-454.
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abstract = "PURPOSE: To determine the sensitivity and specificity of magnetic resonance (MR) imaging for detection of hepatocellular carcinoma (HCC) and dysplastic nodules (DNs) by using explantation correlation in patients with cirrhosis and no known HCC: MATERIALS AND METHODS: Seventy-one patients without a known history of HCC Who underwent MR imaging and subsequent transplantation within 90 days Were examined, Breath-hold turbo short inversion time inversion-recovery and/or T2-weighted turbo spin-echo MR images were obtained. Dynamic two- or three-dimensional gadolinium-enhanced gradient-echo MR images were obtained in the hepatic arterial, portal venous, and equilibrium phases. Prospective MR image interpretations were compared directly with explanted liver pathologic results. RESULTS: Eleven (15{\%}) of 71 patients had hepatic malignancies; MR imaging enabled diagnosis of tumor in six (54{\%}) of 11 patients. On a lesion-by-lesion basis, MR imaging depicted 11 of 20 hepatic neoplasms, for an overall sensitivity of 55{\%}. MR imaging depicted four (80{\%}) of five lesions larger than 2 cm, six (50{\%}) of 12 lesions 1-2 cm, and one (33{\%}) of three lesions smaller than 1 cm. MR imaging depicted only nine (15{\%}) of 59 DNs. The specificities of MR imaging for detection of HCC and DNs on a per patient basis were 60 (86{\%}) of 70 patients and 53(85{\%}) of 62 patients, respectively. CONCLUSION: MR imaging is insensitive for the diagnosis of small (<2-cm) HCCs and DNs.",
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T1 - Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis

T2 - Prospective diagnosis with MR imaging and explantation correlation

AU - Krinsky, G. A.

AU - Lee, V. S.

AU - Theise, N. D.

AU - Weinreb, J. C.

AU - Rofsky, N. M.

AU - Diflo, T.

AU - Teperman, L. W.

PY - 2001

Y1 - 2001

N2 - PURPOSE: To determine the sensitivity and specificity of magnetic resonance (MR) imaging for detection of hepatocellular carcinoma (HCC) and dysplastic nodules (DNs) by using explantation correlation in patients with cirrhosis and no known HCC: MATERIALS AND METHODS: Seventy-one patients without a known history of HCC Who underwent MR imaging and subsequent transplantation within 90 days Were examined, Breath-hold turbo short inversion time inversion-recovery and/or T2-weighted turbo spin-echo MR images were obtained. Dynamic two- or three-dimensional gadolinium-enhanced gradient-echo MR images were obtained in the hepatic arterial, portal venous, and equilibrium phases. Prospective MR image interpretations were compared directly with explanted liver pathologic results. RESULTS: Eleven (15%) of 71 patients had hepatic malignancies; MR imaging enabled diagnosis of tumor in six (54%) of 11 patients. On a lesion-by-lesion basis, MR imaging depicted 11 of 20 hepatic neoplasms, for an overall sensitivity of 55%. MR imaging depicted four (80%) of five lesions larger than 2 cm, six (50%) of 12 lesions 1-2 cm, and one (33%) of three lesions smaller than 1 cm. MR imaging depicted only nine (15%) of 59 DNs. The specificities of MR imaging for detection of HCC and DNs on a per patient basis were 60 (86%) of 70 patients and 53(85%) of 62 patients, respectively. CONCLUSION: MR imaging is insensitive for the diagnosis of small (<2-cm) HCCs and DNs.

AB - PURPOSE: To determine the sensitivity and specificity of magnetic resonance (MR) imaging for detection of hepatocellular carcinoma (HCC) and dysplastic nodules (DNs) by using explantation correlation in patients with cirrhosis and no known HCC: MATERIALS AND METHODS: Seventy-one patients without a known history of HCC Who underwent MR imaging and subsequent transplantation within 90 days Were examined, Breath-hold turbo short inversion time inversion-recovery and/or T2-weighted turbo spin-echo MR images were obtained. Dynamic two- or three-dimensional gadolinium-enhanced gradient-echo MR images were obtained in the hepatic arterial, portal venous, and equilibrium phases. Prospective MR image interpretations were compared directly with explanted liver pathologic results. RESULTS: Eleven (15%) of 71 patients had hepatic malignancies; MR imaging enabled diagnosis of tumor in six (54%) of 11 patients. On a lesion-by-lesion basis, MR imaging depicted 11 of 20 hepatic neoplasms, for an overall sensitivity of 55%. MR imaging depicted four (80%) of five lesions larger than 2 cm, six (50%) of 12 lesions 1-2 cm, and one (33%) of three lesions smaller than 1 cm. MR imaging depicted only nine (15%) of 59 DNs. The specificities of MR imaging for detection of HCC and DNs on a per patient basis were 60 (86%) of 70 patients and 53(85%) of 62 patients, respectively. CONCLUSION: MR imaging is insensitive for the diagnosis of small (<2-cm) HCCs and DNs.

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KW - Liver neoplasms, MR, 761.1 21411 761.121412, 761.121413, 761.121415, 761.12143

KW - Liver, cirrhosis, 761.794

KW - Liver, nodules, 761.3198

KW - Liver, transplantation, 761.459

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