Hepatocellular transport: Role of ATP-binding cassette proteins

Noureddine Lomri, J. Gregory Fitz, Bruce F. Scharschmidt

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The interest of mammalian biologists in ATP-binding cassette (ABC) proteins is relatively recent. However, ABC proteins care widespread in distribution and have long been known to play an important transport role in prokaryotes. This review includes a brief overview of the structure, regulation, and varied functions of ABC proteins in different cell types as well as a synopsis of the emerging role of ABC proteins in human biology and disease. The review then focuses on the established (canalicular secretion of organic cations by the multidrug resistance, or MDR 1, gene product; ductular secretion of fluid and electrolytes mediated by CFTR), probable (biliary phospholipid secretion by the MDR 2 gene product; secretion of non-bile acid organic anions by the multidrug resistance protein, or MRP), and possible (bile acid secretion; biliary secretion of the signaling molecule, ATP; hormone transport) roles of known and novel ABC proteins in hepatobiliary secretion.

Original languageEnglish (US)
Pages (from-to)201-210
Number of pages10
JournalSeminars in Liver Disease
Volume16
Issue number2
StatePublished - 1996

Fingerprint

Carrier Proteins
Adenosine Triphosphate
MDR Genes
P-Glycoproteins
Fluids and Secretions
Multiple Drug Resistance
Bile Acids and Salts
Electrolytes
Anions
Cations
Phospholipids
Hormones
Acids

Keywords

  • adenosine nucleotides
  • bile secretion
  • multidrug resistance
  • organic anions

ASJC Scopus subject areas

  • Hepatology

Cite this

Hepatocellular transport : Role of ATP-binding cassette proteins. / Lomri, Noureddine; Fitz, J. Gregory; Scharschmidt, Bruce F.

In: Seminars in Liver Disease, Vol. 16, No. 2, 1996, p. 201-210.

Research output: Contribution to journalArticle

Lomri, N, Fitz, JG & Scharschmidt, BF 1996, 'Hepatocellular transport: Role of ATP-binding cassette proteins', Seminars in Liver Disease, vol. 16, no. 2, pp. 201-210.
Lomri, Noureddine ; Fitz, J. Gregory ; Scharschmidt, Bruce F. / Hepatocellular transport : Role of ATP-binding cassette proteins. In: Seminars in Liver Disease. 1996 ; Vol. 16, No. 2. pp. 201-210.
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