Hepatocellular transport: Role of ATP-binding cassette proteins

Noureddine Lomri, J. Gregory Fitz, Bruce F. Scharschmidt

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

The interest of mammalian biologists in ATP-binding cassette (ABC) proteins is relatively recent. However, ABC proteins care widespread in distribution and have long been known to play an important transport role in prokaryotes. This review includes a brief overview of the structure, regulation, and varied functions of ABC proteins in different cell types as well as a synopsis of the emerging role of ABC proteins in human biology and disease. The review then focuses on the established (canalicular secretion of organic cations by the multidrug resistance, or MDR 1, gene product; ductular secretion of fluid and electrolytes mediated by CFTR), probable (biliary phospholipid secretion by the MDR 2 gene product; secretion of non-bile acid organic anions by the multidrug resistance protein, or MRP), and possible (bile acid secretion; biliary secretion of the signaling molecule, ATP; hormone transport) roles of known and novel ABC proteins in hepatobiliary secretion.

Original languageEnglish (US)
Pages (from-to)201-210
Number of pages10
JournalSeminars in Liver Disease
Volume16
Issue number2
DOIs
StatePublished - Jan 1 1996

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Keywords

  • adenosine nucleotides
  • bile secretion
  • multidrug resistance
  • organic anions

ASJC Scopus subject areas

  • Hepatology

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