TY - JOUR
T1 - Hepatocyte-specific mutation establishes retinoid X receptor α as a heterodimeric integrator of multiple physiological processes in the liver
AU - Wan, Yu Jui Yvonne
AU - An, Dahsing
AU - Cai, Yan
AU - Repa, Joyce J.
AU - Chen, Tim Hung Po
AU - Flores, Monica
AU - Postic, Catherine
AU - Magnuson, Mark A.
AU - Chen, Ju
AU - Chien, Kenneth R.
AU - French, Samuel
AU - Mangelsdorf, David J.
AU - Sucov, Henry M.
PY - 2000/6
Y1 - 2000/6
N2 - A large number of physiological processes in the adult liver are regulated by nuclear receptors that require heterodimerization with retinoid X receptors (RXRs). In this study, we have used cre-mediated recombination to disrupt the mouse RXRα gene specifically in hepatocytes. Although such mice are viable, molecular and biochemical parameters indicate that every one of the examined metabolic pathways in the liver (mediated by RXR heterodimerization with PPARα, CARβ, PXR, LXR, and FXR) is compromised in the absence of RXRα. These data demonstrate the presence of a complex circuitry in which RXRα is integrated into a number of diverse physiological pathways as a common regulatory component of cholesterol, fatty acid, bile acid, steroid, and xenobiotic metabolism and homeostasis.
AB - A large number of physiological processes in the adult liver are regulated by nuclear receptors that require heterodimerization with retinoid X receptors (RXRs). In this study, we have used cre-mediated recombination to disrupt the mouse RXRα gene specifically in hepatocytes. Although such mice are viable, molecular and biochemical parameters indicate that every one of the examined metabolic pathways in the liver (mediated by RXR heterodimerization with PPARα, CARβ, PXR, LXR, and FXR) is compromised in the absence of RXRα. These data demonstrate the presence of a complex circuitry in which RXRα is integrated into a number of diverse physiological pathways as a common regulatory component of cholesterol, fatty acid, bile acid, steroid, and xenobiotic metabolism and homeostasis.
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U2 - 10.1128/MCB.20.12.4436-4444.2000
DO - 10.1128/MCB.20.12.4436-4444.2000
M3 - Article
C2 - 10825207
AN - SCOPUS:0034035667
SN - 0270-7306
VL - 20
SP - 4436
EP - 4444
JO - Molecular and cellular biology
JF - Molecular and cellular biology
IS - 12
ER -