Abstract
In light of the significant clinical benefits of novel HER2-targeting antibody-drug conjugates in advanced HER2-low expressing breast cancers in recent phases I and III clinical trials, particularly trastuzumab-deruxtecan (T-Dxd), the new “HER2-low” category in breast cancers (breast cancer with a HER2 IHC score of 1+, or 2+ without gene amplification) has gained increasing attention. In the past year, “HER2-low” breast cancers have been under active investigation by both oncologists and pathologists. In this current review, we update the recent cutting-edge research on HER2-low breast cancers, with a focus on the biology of HER2-low breast cancers, the issues on the identification of HER2-low breast cancers by immunohistochemistry in current practice of pathology, and the future directions in this emerging category in breast cancers.
Original language | English (US) |
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Pages (from-to) | 305-312 |
Number of pages | 8 |
Journal | Seminars in Diagnostic Pathology |
Volume | 39 |
Issue number | 5 |
DOIs | |
State | Published - Sep 2022 |
Keywords
- Biology
- Breast cancer
- HER2
- HER2-low
- Pathology
- T-Dxd
- Trastuzumab-deruxtecan
ASJC Scopus subject areas
- Pathology and Forensic Medicine