Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible genelike receptors, which synergize to induce type I interferon production

Simon B. Rasmussen, Søren B. Jensen, Christoffer Nielsen, Emanuel Quartin, Hiroki Kato, Zhijian J. Chen, Robert H. Silverman, Shizuo Akira, Søren R. Paludan

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

The innate antiviral response is initiated by pattern recognition receptors, which recognize viral pathogen-associated molecular patterns. Here we show that retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) in cooperation with Toll-like receptor (TLR) 9 is required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV). Our work also identified RNase L as a critical component in IFN induction. Moreover, we found that TLR9 and RLRs activate distinct, as well as overlapping, intracellular signalling pathways. Thus, RLRs are important for recognition of HSV infection, and cooperate with the Toll pathway to induce an antiviral response.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
JournalJournal of General Virology
Volume90
Issue number1
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Virology

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