Heterocycles via intramolecular platinum-catalyzed propargylic substitution

Qiren Liang, Jef K. De Brabander

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We report a Pt(II)-catalyzed cyclization of nucleophile-tethered propargylic acetates yielding substituted heterocycles containing multiple heteroatoms including morpholines, dioxanes, and sulfamates with high cis-selectivity.

Original languageEnglish (US)
Pages (from-to)5046-5053
Number of pages8
JournalTetrahedron
Volume67
Issue number27-28
DOIs
StatePublished - Jul 8 2011

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Keywords

  • Dioxanes
  • Morpholines
  • Platinum catalysis
  • Propargylic substitution
  • Sulfamates
  • Tetrahydropyrans

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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