Heterocycles via intramolecular platinum-catalyzed propargylic substitution

Qiren Liang, Jef K. De Brabander

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We report a Pt(II)-catalyzed cyclization of nucleophile-tethered propargylic acetates yielding substituted heterocycles containing multiple heteroatoms including morpholines, dioxanes, and sulfamates with high cis-selectivity.

Original languageEnglish (US)
Pages (from-to)5046-5053
Number of pages8
JournalTetrahedron
Volume67
Issue number27-28
DOIs
StatePublished - Jul 8 2011

Fingerprint

Morpholines
Dioxanes
Nucleophiles
Cyclization
Platinum
Acetates
Substitution reactions
sulfamic acid

Keywords

  • Dioxanes
  • Morpholines
  • Platinum catalysis
  • Propargylic substitution
  • Sulfamates
  • Tetrahydropyrans

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Heterocycles via intramolecular platinum-catalyzed propargylic substitution. / Liang, Qiren; De Brabander, Jef K.

In: Tetrahedron, Vol. 67, No. 27-28, 08.07.2011, p. 5046-5053.

Research output: Contribution to journalArticle

@article{6e43a395652a42eea76c222a349d7a9d,
title = "Heterocycles via intramolecular platinum-catalyzed propargylic substitution",
abstract = "We report a Pt(II)-catalyzed cyclization of nucleophile-tethered propargylic acetates yielding substituted heterocycles containing multiple heteroatoms including morpholines, dioxanes, and sulfamates with high cis-selectivity.",
keywords = "Dioxanes, Morpholines, Platinum catalysis, Propargylic substitution, Sulfamates, Tetrahydropyrans",
author = "Qiren Liang and {De Brabander}, {Jef K.}",
year = "2011",
month = "7",
day = "8",
doi = "10.1016/j.tet.2011.03.115",
language = "English (US)",
volume = "67",
pages = "5046--5053",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "27-28",

}

TY - JOUR

T1 - Heterocycles via intramolecular platinum-catalyzed propargylic substitution

AU - Liang, Qiren

AU - De Brabander, Jef K.

PY - 2011/7/8

Y1 - 2011/7/8

N2 - We report a Pt(II)-catalyzed cyclization of nucleophile-tethered propargylic acetates yielding substituted heterocycles containing multiple heteroatoms including morpholines, dioxanes, and sulfamates with high cis-selectivity.

AB - We report a Pt(II)-catalyzed cyclization of nucleophile-tethered propargylic acetates yielding substituted heterocycles containing multiple heteroatoms including morpholines, dioxanes, and sulfamates with high cis-selectivity.

KW - Dioxanes

KW - Morpholines

KW - Platinum catalysis

KW - Propargylic substitution

KW - Sulfamates

KW - Tetrahydropyrans

UR - http://www.scopus.com/inward/record.url?scp=79958695955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958695955&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2011.03.115

DO - 10.1016/j.tet.2011.03.115

M3 - Article

C2 - 21731116

AN - SCOPUS:79958695955

VL - 67

SP - 5046

EP - 5053

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 27-28

ER -