Abstract
Purpose: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. Methods: The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of sourcedetector pairs (106). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements. Results: The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. Conclusions: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated.
Original language | English (US) |
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Pages (from-to) | 4383-4395 |
Number of pages | 13 |
Journal | Medical physics |
Volume | 43 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2016 |
Externally published | Yes |
Keywords
- CCD-based optical tomography instrumentation
- breast cancer imaging
- diffuse optical tomography
- optical mammography
ASJC Scopus subject areas
- Biophysics
- Radiology Nuclear Medicine and imaging