Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

Mark Shackleton, Elsa Quintana, Eric R. Fearon, Sean J. Morrison

Research output: Contribution to journalShort survey

754 Scopus citations

Abstract

The identification and characterization of cancer stem cells might lead to more effective treatments for some cancers by focusing therapy on the most malignant cells. To achieve this goal it will be necessary to determine which cancers follow a cancer stem cell model and which do not, to address technical issues related to tumorigenesis assays, and to test the extent to which cancer cell heterogeneity arises from genetic versus epigenetic differences.

Original languageEnglish (US)
Pages (from-to)822-829
Number of pages8
JournalCell
Volume138
Issue number5
DOIs
StatePublished - Sep 4 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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