Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

Mark Shackleton, Elsa Quintana, Eric R. Fearon, Sean J. Morrison

Research output: Contribution to journalArticle

715 Citations (Scopus)

Abstract

The identification and characterization of cancer stem cells might lead to more effective treatments for some cancers by focusing therapy on the most malignant cells. To achieve this goal it will be necessary to determine which cancers follow a cancer stem cell model and which do not, to address technical issues related to tumorigenesis assays, and to test the extent to which cancer cell heterogeneity arises from genetic versus epigenetic differences.

Original languageEnglish (US)
Pages (from-to)822-829
Number of pages8
JournalCell
Volume138
Issue number5
DOIs
StatePublished - Sep 4 2009

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Clonal Evolution
Neoplastic Stem Cells
Stem cells
Assays
Neoplasms
Genetic Heterogeneity
Cells
Epigenomics
Carcinogenesis
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Heterogeneity in Cancer : Cancer Stem Cells versus Clonal Evolution. / Shackleton, Mark; Quintana, Elsa; Fearon, Eric R.; Morrison, Sean J.

In: Cell, Vol. 138, No. 5, 04.09.2009, p. 822-829.

Research output: Contribution to journalArticle

Shackleton, Mark ; Quintana, Elsa ; Fearon, Eric R. ; Morrison, Sean J. / Heterogeneity in Cancer : Cancer Stem Cells versus Clonal Evolution. In: Cell. 2009 ; Vol. 138, No. 5. pp. 822-829.
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