TY - JOUR
T1 - Heterogeneous astrocytes
T2 - Active players in CNS
AU - Hu, Xin
AU - Yuan, Yimin
AU - Wang, Dan
AU - Su, Zhida
N1 - Funding Information:
This work was supported by the National Natural Science Foundation ( 81271352 , 31171124 ), Shanghai Pujiang Program ( 15PJ1410500 ), and Science and Technology Commission of Shanghai Municipality ( 15JC1400202 ).
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Astrocytes, the predominant cell type that are broadly distributed in the brain and spinal cord, play key roles in maintaining homeostasis of the central nerve system (CNS) in physiological and pathological conditions. Increasing evidence indicates that astrocytes are a complex colony with heterogeneity on morphology, gene expression, function and many other aspects depending on their spatio-temporal distribution and activation level. In pathological conditions, astrocytes differentially respond to all kinds of insults, including injury and disease, and participate in the neuropathological process. Based on current studies, we here give an overview of the roles of heterogeneous astrocytes in CNS, especially in neuropathologies, which focuses on biological and functional diversity of astrocytes. We propose that a precise understanding of the heterogeneous astrocytes is critical to unlocking the secrets about pathogenesis and treatment of the mazy CNS.
AB - Astrocytes, the predominant cell type that are broadly distributed in the brain and spinal cord, play key roles in maintaining homeostasis of the central nerve system (CNS) in physiological and pathological conditions. Increasing evidence indicates that astrocytes are a complex colony with heterogeneity on morphology, gene expression, function and many other aspects depending on their spatio-temporal distribution and activation level. In pathological conditions, astrocytes differentially respond to all kinds of insults, including injury and disease, and participate in the neuropathological process. Based on current studies, we here give an overview of the roles of heterogeneous astrocytes in CNS, especially in neuropathologies, which focuses on biological and functional diversity of astrocytes. We propose that a precise understanding of the heterogeneous astrocytes is critical to unlocking the secrets about pathogenesis and treatment of the mazy CNS.
KW - Astrocyte
KW - CNS injury
KW - Function
KW - Heterogeneity
KW - Neurological disease
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U2 - 10.1016/j.brainresbull.2016.03.017
DO - 10.1016/j.brainresbull.2016.03.017
M3 - Review article
C2 - 27021168
AN - SCOPUS:84962288692
SN - 0361-9230
VL - 125
SP - 1
EP - 18
JO - Brain Research Bulletin
JF - Brain Research Bulletin
ER -