Heterogeneous nucleation with urate, calcium phosphate and calcium oxalate

C. Y C Pak, Y. Hayashi, L. H. Arnold

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Heterogeneous nucleation may constitute one of the mechanisms for the formation of renal stones of mixed composition. This process allows heterogeneous nuclei to initiate precipitation from solutions which are metastably supersaturated with respect to the precipitate. The seed of monosodium urate monohydrate, but not of uric acid, was capable of provoking nucleation of Ca phosphate and Ca oxalate. Conversely, seeds of brushite, hydroxyapatite, and Ca oxalate caused nucleation of monosodium urate, but not of uric acid. The seed of hydroxyapatite initiated precipitation of Ca oxalate and vice versa. These physicochemical experiments provide a basis for the explanation of the formation of mixed stones.

Original languageEnglish (US)
Pages (from-to)83-87
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume153
Issue number1
StatePublished - 1976

Fingerprint

Calcium Oxalate
Uric Acid
Oxalates
Nucleation
Seed
Seeds
Durapatite
Precipitates
Phosphates
Kidney
calcium phosphate
Chemical analysis
Experiments

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Heterogeneous nucleation with urate, calcium phosphate and calcium oxalate. / Pak, C. Y C; Hayashi, Y.; Arnold, L. H.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 153, No. 1, 1976, p. 83-87.

Research output: Contribution to journalArticle

@article{bee83ba1979e46f496da926e576c3d7c,
title = "Heterogeneous nucleation with urate, calcium phosphate and calcium oxalate",
abstract = "Heterogeneous nucleation may constitute one of the mechanisms for the formation of renal stones of mixed composition. This process allows heterogeneous nuclei to initiate precipitation from solutions which are metastably supersaturated with respect to the precipitate. The seed of monosodium urate monohydrate, but not of uric acid, was capable of provoking nucleation of Ca phosphate and Ca oxalate. Conversely, seeds of brushite, hydroxyapatite, and Ca oxalate caused nucleation of monosodium urate, but not of uric acid. The seed of hydroxyapatite initiated precipitation of Ca oxalate and vice versa. These physicochemical experiments provide a basis for the explanation of the formation of mixed stones.",
author = "Pak, {C. Y C} and Y. Hayashi and Arnold, {L. H.}",
year = "1976",
language = "English (US)",
volume = "153",
pages = "83--87",
journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",
issn = "1535-3702",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - Heterogeneous nucleation with urate, calcium phosphate and calcium oxalate

AU - Pak, C. Y C

AU - Hayashi, Y.

AU - Arnold, L. H.

PY - 1976

Y1 - 1976

N2 - Heterogeneous nucleation may constitute one of the mechanisms for the formation of renal stones of mixed composition. This process allows heterogeneous nuclei to initiate precipitation from solutions which are metastably supersaturated with respect to the precipitate. The seed of monosodium urate monohydrate, but not of uric acid, was capable of provoking nucleation of Ca phosphate and Ca oxalate. Conversely, seeds of brushite, hydroxyapatite, and Ca oxalate caused nucleation of monosodium urate, but not of uric acid. The seed of hydroxyapatite initiated precipitation of Ca oxalate and vice versa. These physicochemical experiments provide a basis for the explanation of the formation of mixed stones.

AB - Heterogeneous nucleation may constitute one of the mechanisms for the formation of renal stones of mixed composition. This process allows heterogeneous nuclei to initiate precipitation from solutions which are metastably supersaturated with respect to the precipitate. The seed of monosodium urate monohydrate, but not of uric acid, was capable of provoking nucleation of Ca phosphate and Ca oxalate. Conversely, seeds of brushite, hydroxyapatite, and Ca oxalate caused nucleation of monosodium urate, but not of uric acid. The seed of hydroxyapatite initiated precipitation of Ca oxalate and vice versa. These physicochemical experiments provide a basis for the explanation of the formation of mixed stones.

UR - http://www.scopus.com/inward/record.url?scp=0017052703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017052703&partnerID=8YFLogxK

M3 - Article

VL - 153

SP - 83

EP - 87

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

SN - 1535-3702

IS - 1

ER -