Heterologous prime-boost immunizations with different Salmonella serovars for enhanced antigen-specific CD8 T-cell induction

Victòria E. Sevil Domènech, Klaus Panthel, Sebastian E. Winter, Holger Rüssmann

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Pre-existing anti-vector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. In the present study, we demonstrate that heterologous prime-boost immunizations using attenuated serovar Typhimurium and serovar Dublin strains for foreign antigen delivery can be employed to bypass anti-Salmonella immunity resulting in enhanced antigen-specific CD8 T-cell induction. This desirable effect can be explained by the fact that, in contrast to homologous prime-boost immunizations, vaccination with different Salmonella serovars is characterized by long-lasting colonization of mice by both live carrier vaccines.

Original languageEnglish (US)
Pages (from-to)1879-1886
Number of pages8
JournalVaccine
Volume26
Issue number15
DOIs
StatePublished - Mar 28 2008

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CD8 Antigens
Salmonella
Immunization
immunization
serotypes
T-lymphocytes
antigens
T-Lymphocytes
immunity
type III secretion system
Immunity
Vaccines
protein transport
mice
live vaccines
Salmonella Typhimurium
Salmonella enterica
Protein Transport
vaccination
vaccines

Keywords

  • Anti-vector immunity
  • CD8 T cell
  • Heterologous prime-boost immunizations
  • Salmonella enterica serovar Typhimurium and serovar Dublin
  • Type III secretion system

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Heterologous prime-boost immunizations with different Salmonella serovars for enhanced antigen-specific CD8 T-cell induction. / Sevil Domènech, Victòria E.; Panthel, Klaus; Winter, Sebastian E.; Rüssmann, Holger.

In: Vaccine, Vol. 26, No. 15, 28.03.2008, p. 1879-1886.

Research output: Contribution to journalArticle

Sevil Domènech, Victòria E. ; Panthel, Klaus ; Winter, Sebastian E. ; Rüssmann, Holger. / Heterologous prime-boost immunizations with different Salmonella serovars for enhanced antigen-specific CD8 T-cell induction. In: Vaccine. 2008 ; Vol. 26, No. 15. pp. 1879-1886.
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