Heterologous prime-boost immunizations with different Salmonella serovars for enhanced antigen-specific CD8 T-cell induction

Victòria E. Sevil Domènech, Klaus Panthel, Sebastian E. Winter, Holger Rüssmann

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Pre-existing anti-vector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. In the present study, we demonstrate that heterologous prime-boost immunizations using attenuated serovar Typhimurium and serovar Dublin strains for foreign antigen delivery can be employed to bypass anti-Salmonella immunity resulting in enhanced antigen-specific CD8 T-cell induction. This desirable effect can be explained by the fact that, in contrast to homologous prime-boost immunizations, vaccination with different Salmonella serovars is characterized by long-lasting colonization of mice by both live carrier vaccines.

Original languageEnglish (US)
Pages (from-to)1879-1886
Number of pages8
JournalVaccine
Volume26
Issue number15
DOIs
StatePublished - Mar 28 2008

Keywords

  • Anti-vector immunity
  • CD8 T cell
  • Heterologous prime-boost immunizations
  • Salmonella enterica serovar Typhimurium and serovar Dublin
  • Type III secretion system

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Heterologous prime-boost immunizations with different Salmonella serovars for enhanced antigen-specific CD8 T-cell induction'. Together they form a unique fingerprint.

  • Cite this