Heterotopic Ossification and Hypertrophic Scars

Shailesh Agarwal, Michael Sorkin, Benjamin Levi

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Burns and trauma cause superficial and deep soft tissue wounds that cannot heal to the preinjury state. Healing requires cell proliferation and differentiation into the injured tissue type, laying down extracellular matrix, often as collagens. Heterotopic ossification causes severe pain, nonhealing wounds, and restricted range of motion. Treatment includes radiation therapy, nonsteroidal anti-inflammatory drugs, bisphosphonates, and possibly surgical excision and prophylactic measures. Hypertrophic scars, nonosseous lesions caused by excessive collagen deposition, are often painful, functionally limiting, and aesthetically displeasing. Treatment includes CO2 laser application, steroid injections, and excision with skin grafting. This article reviews the management of these pathologic wounds.

Original languageEnglish (US)
Pages (from-to)749-755
Number of pages7
JournalClinics in Plastic Surgery
Volume44
Issue number4
DOIs
StatePublished - Oct 2017
Externally publishedYes

Keywords

  • Burn injury
  • Heterotopic ossification
  • Hypertrophic scar

ASJC Scopus subject areas

  • Surgery

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