High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

Barbara L. Hempstead, Dionisio Martin-Zanca, David R. Kaplan, Luis F. Parada, Moses V. Chao

Research output: Contribution to journalArticle

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Abstract

Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity NGF binding requires coexpression and binding to both the low-affinity NGF receptor and the tyrosine kinase trk gene product. These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor.

Original languageEnglish (US)
Pages (from-to)678-683
Number of pages6
JournalNature
Volume350
Issue number6320
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

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    Hempstead, B. L., Martin-Zanca, D., Kaplan, D. R., Parada, L. F., & Chao, M. V. (1991). High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature, 350(6320), 678-683. https://doi.org/10.1038/350678a0