High concentrations of naloxone attenuate N-methyl-D-aspartate receptor-mediated neurotoxicity

Janice P. Kim, Mark P. Goldberg, Dennis W. Choi

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

(-)-Naloxone, 1 mM, partially reduced neuronal loss induced by exposure of murine cortical cell cultures to N-methyl-D-aspartate (NMDA) or quinolinate, but produced little or no attenuation of kainate or quisqualate neurotoxicity. Antagonism of NMDA neurotoxicity was (-)-naloxone concentration-dependent between 100 μM and 3 mM. (+)-Naloxone produced a slightly greater reduction of NMDA neurotoxicity, arguing against mediation by opioid receptors. Although this novel neuron-protective action of (-)-naloxone was weak, it may contribute to reported beneficial effects in CNS ischemia.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalEuropean Journal of Pharmacology
Volume138
Issue number1
DOIs
StatePublished - Jun 12 1987

Keywords

  • (Cell culture)
  • N-Methyl-D-aspartate
  • Naloxone
  • Neocortex
  • Neurotoxicity

ASJC Scopus subject areas

  • Pharmacology

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