High-definition transcranial direct current stimulation to improve verbal retrieval deficits in chronic traumatic brain injury

Michael A. Motes, Jeffrey S Spence, Kylee Yeatman, Penelope M. Jones, Morgan Lutrell, Rachel O'Hair, Scott Shakal, Bambi L. Delarosa, Wing To, Sven Vanneste, Michael A. Kraut, John Hart

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Chronic verbal retrieval deficits have been noted in traumatic brain injury (TBI), but no U.S. Food and Drug Administration-approved interventions are available. The present study investigated whether 10 sessions of 20 min of 1 mA anodal high-definition transcranial direct current stimulation (HD-tDCS) targeting pre-supplementary motor area/dorsal anterior cingulate cortex (preSMA/dACC) compared with sham HD-tDCS would improve verbal retrieval deficits in TBI patients. Improvements in verbal retrieval processes were observed up to 8 weeks post-treatment. Thus, potential dysfunction to verbal retrieval circuitry in TBI appears amenable to remediation through electromodulation with HD tDCS to the preSMA/dACC. Although further studies clarifying mechanisms by which tDCS brought about these improvements will likely inform refinements in the application of this therapeutic technique, the findings suggest the efficacy of using HD-tDCS to target other systems vulnerable to TBI to improve functioning.

Original languageEnglish (US)
Pages (from-to)170-177
Number of pages8
JournalJournal of neurotrauma
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2020

Keywords

  • learning and memory
  • neuroplasticity
  • rehabilitation
  • traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology

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