High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer

Jennifer Taylor Veneris, Kathleen M. Darcy, Paulette Mhawech-Fauceglia, Chunqiao Tian, Ernst Lengyel, Ricardo R. Lastra, Tanja Pejovic, Suzanne D. Conzen, Gini F. Fleming

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective To investigate the association of tumor glucocorticoid receptor (GR) expression and patient outcome in ovarian cancer. Methods GR expression was evaluated by immunohistochemistry using tissue microarrays of specimens from 481 patients with ovarian cancer and 4 patients with benign conditions. Low GR expression was defined as an intensity of 0 or 1 + and high GR as 2 + or 3 + in > 1% of tumor cells. Analyses were performed to evaluate the relationship of GR expression with clinical characteristics, progression-free survival (PFS) and overall survival (OS). Results GR protein was highly expressed in 133 of 341 (39.0%) tumors from patients who underwent upfront cytoreduction surgery followed by adjuvant chemotherapy. High GR expression was more common in serous tumors (p < 0.001), high grade tumors (p < 0.001), and advanced stage tumors (p = 0.037). Median PFS was significantly decreased in cases with high GR (20.4 months) compared to those with low GR (36.0 months, HR = 1.66, 95% CI 1.29–2.14, p < 0.001). GR remained an independent prognostic factor for PFS in multivariate analysis. OS was not associated with GR status. Conclusions These data suggest that high GR expression correlates with poor prognosis and support the hypothesis that modulating GR activity in combination with chemotherapy may improve outcomes.

Original languageEnglish (US)
Pages (from-to)153-160
Number of pages8
JournalGynecologic Oncology
Volume146
Issue number1
DOIs
StatePublished - Jul 2017
Externally publishedYes

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Keywords

  • Epithelial ovarian cancer
  • Glucocorticoid receptor
  • Hormone receptor
  • Survival
  • Tumor markers

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Veneris, J. T., Darcy, K. M., Mhawech-Fauceglia, P., Tian, C., Lengyel, E., Lastra, R. R., Pejovic, T., Conzen, S. D., & Fleming, G. F. (2017). High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer. Gynecologic Oncology, 146(1), 153-160. https://doi.org/10.1016/j.ygyno.2017.04.012