High levels of foot ulceration and amputation risk in a multiracial cohort of diabetic patients on dialysis therapy

Agbor Ndip, Lawrence A. Lavery, Javier Lafontaine, Martin K. Rutter, Anand Vardhan, Loretta Vileikyte, Andrew J M Boulton

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE- To evaluate the prevalence of lower-limb complications in a multiracial cohort of patients with diabetes receiving dialysis. RESEARCH DESIGN AND METHODS- This work was a cross-sectional study of lower-limb complications in dialysis-treated patients with diabetes in the U.K. and U.S. RESULTS- We studied 466 patients (139 U.K.; 327 U.S.). The prevalence of lower-limb complications was high (foot ulcers 12%, neuropathy 79%, peripheral arterial disease 57%, history of foot ulceration 34%, and prior amputation 18%), with no significant ethnic variation, except that foot ulcers were more common in whites than in patients of African descent (P = 0.013). Ninety-five percent of patients were at high risk of lower-limb complications. Prior amputation was related to foot ulcer history, peripheral arterial disease, and hemodialysis modality in multivariable analysis. Prevalent ulceration showed independent associations with foot ulcer history and peripheral arterial disease, but not with ethnicity. CONCLUSIONS- All patients with diabetes receiving dialysis are at high risk of lower-limb complications independent of ethnic background.

Original languageEnglish (US)
Pages (from-to)878-880
Number of pages3
JournalDiabetes Care
Volume33
Issue number4
DOIs
StatePublished - Apr 2010

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Amputation
Foot Ulcer
Foot
Dialysis
Lower Extremity
Peripheral Arterial Disease
Therapeutics
Renal Dialysis
Research Design
Cross-Sectional Studies

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

High levels of foot ulceration and amputation risk in a multiracial cohort of diabetic patients on dialysis therapy. / Ndip, Agbor; Lavery, Lawrence A.; Lafontaine, Javier; Rutter, Martin K.; Vardhan, Anand; Vileikyte, Loretta; Boulton, Andrew J M.

In: Diabetes Care, Vol. 33, No. 4, 04.2010, p. 878-880.

Research output: Contribution to journalArticle

Ndip, Agbor ; Lavery, Lawrence A. ; Lafontaine, Javier ; Rutter, Martin K. ; Vardhan, Anand ; Vileikyte, Loretta ; Boulton, Andrew J M. / High levels of foot ulceration and amputation risk in a multiracial cohort of diabetic patients on dialysis therapy. In: Diabetes Care. 2010 ; Vol. 33, No. 4. pp. 878-880.
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AU - Vardhan, Anand

AU - Vileikyte, Loretta

AU - Boulton, Andrew J M

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N2 - OBJECTIVE- To evaluate the prevalence of lower-limb complications in a multiracial cohort of patients with diabetes receiving dialysis. RESEARCH DESIGN AND METHODS- This work was a cross-sectional study of lower-limb complications in dialysis-treated patients with diabetes in the U.K. and U.S. RESULTS- We studied 466 patients (139 U.K.; 327 U.S.). The prevalence of lower-limb complications was high (foot ulcers 12%, neuropathy 79%, peripheral arterial disease 57%, history of foot ulceration 34%, and prior amputation 18%), with no significant ethnic variation, except that foot ulcers were more common in whites than in patients of African descent (P = 0.013). Ninety-five percent of patients were at high risk of lower-limb complications. Prior amputation was related to foot ulcer history, peripheral arterial disease, and hemodialysis modality in multivariable analysis. Prevalent ulceration showed independent associations with foot ulcer history and peripheral arterial disease, but not with ethnicity. CONCLUSIONS- All patients with diabetes receiving dialysis are at high risk of lower-limb complications independent of ethnic background.

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