High levels of intracellular bombesin characterize human small-cell lung carcinoma

Terry W. Moody, Candace B. Pert, Adi F. Gazdar, Desmond N. Carney, John D. Minna

Research output: Contribution to journalArticle

382 Citations (Scopus)

Abstract

"Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease.

Original languageEnglish (US)
Pages (from-to)1246-1248
Number of pages3
JournalScience
Volume214
Issue number4526
StatePublished - 1981

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Bombesin
Small Cell Lung Carcinoma
Lung Neoplasms
Cell Line
Neuropeptides
Neurons
Lung
Peptides

ASJC Scopus subject areas

  • General

Cite this

Moody, T. W., Pert, C. B., Gazdar, A. F., Carney, D. N., & Minna, J. D. (1981). High levels of intracellular bombesin characterize human small-cell lung carcinoma. Science, 214(4526), 1246-1248.

High levels of intracellular bombesin characterize human small-cell lung carcinoma. / Moody, Terry W.; Pert, Candace B.; Gazdar, Adi F.; Carney, Desmond N.; Minna, John D.

In: Science, Vol. 214, No. 4526, 1981, p. 1246-1248.

Research output: Contribution to journalArticle

Moody, TW, Pert, CB, Gazdar, AF, Carney, DN & Minna, JD 1981, 'High levels of intracellular bombesin characterize human small-cell lung carcinoma', Science, vol. 214, no. 4526, pp. 1246-1248.
Moody TW, Pert CB, Gazdar AF, Carney DN, Minna JD. High levels of intracellular bombesin characterize human small-cell lung carcinoma. Science. 1981;214(4526):1246-1248.
Moody, Terry W. ; Pert, Candace B. ; Gazdar, Adi F. ; Carney, Desmond N. ; Minna, John D. / High levels of intracellular bombesin characterize human small-cell lung carcinoma. In: Science. 1981 ; Vol. 214, No. 4526. pp. 1246-1248.
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