High-mobility group box 1 and cancer

Daolin Tang, Rui Kang, Herbert J. Zeh, Michael T. Lotze

Research output: Contribution to journalReview article

370 Scopus citations

Abstract

High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily ancient and critical regulator of cell death and survival. Overexpression of HMGB1 is associated with each of the hallmarks of cancer including unlimited replicative potential, ability to develop blood vessels (angiogenesis), evasion of programmed cell death (apoptosis), self-sufficiency in growth signals, insensitivity to inhibitors of growth, inflammation, tissue invasion and metastasis. Our studies and those of our colleagues suggest that HMGB1 is central to cancer (abnormal wound healing) and many of the findings in normal wound healing as well. Here, we focus on the role of HMGB1 in cancer, the mechanisms by which it contributes to carcinogenesis, and therapeutic strategies based on targeting HMGB1.

Original languageEnglish (US)
Pages (from-to)131-140
Number of pages10
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1799
Issue number1-2
DOIs
StatePublished - Jan 1 2010

    Fingerprint

Keywords

  • Angiogenesis
  • Autophagy
  • CD24
  • Cancer
  • Damage associated molecular pattern molecule [DAMP]
  • Field effect
  • HMGB1
  • Hallmarks of cancer
  • Inflammation
  • Receptor for advanced glycation endproducts [RAGE]
  • TLR2
  • TLR4
  • TLR9

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this