High-order epistasis in catalytic power of dihydrofolate reductase gives rise to a rugged fitness landscape in the presence of trimethoprim selection

Yusuf Talha Tamer, Ilona K. Gaszek, Haleh Abdizadeh, Tugce Altinusak Batur, Kimberly A. Reynolds, Ali Rana Atilgan, Canan Atilgan, Erdal Toprak

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