High resolution computed tomography atlas of the porcine temporal bone and skull base: Anatomical correlates for traumatic brain injury research

Renata M. Knoll, Katherine L. Reinshagen, Samuel R. Barber, Iman Ghanad, Randel Swanson, Douglas H. Smith, Kalil G. Abdullah, David H. Jung, Aaron K. Remenschneider, Elliott D. Kozin

Research output: Contribution to journalArticle

Abstract

Brain injuries are a significant cause of morbidity and mortality worldwide. Auditory and vestibular dysfunction may occur following trauma to the temporal bone (TB), including the lateral skull base. The porcine model is a commonly used large animal model for investigating brain injury. Reports detailing porcine TB anatomy based on high resolution computed tomography (HRCT) imaging, however, are limited. Herein, we employ HRCT to evaluate and describe the bony anatomy of the porcine TB and lateral skull base. High-resolution multi-detector and cone beam CT were used to image porcine TBs (n = 16). TBs were analyzed for major anatomical structures and compared to human species. Porcine temporal bone anatomy was readily identifiable by HRCT. Although some variability exists, the ossicular chain, vestibule, cochlea, course of the facial nerve, and skull base are similar to those of humans. Major differences included position of the external auditory canal and mastoid, as well as presence of the petrous carotid canal. Study findings may serve as an atlas to evaluate the porcine middle and inner ear, as well as lateral skull base injuries for future porcine brain injury models or other studies that require CT-based analysis.

Original languageEnglish (US)
Pages (from-to)1029-1039
Number of pages11
JournalJournal of neurotrauma
Volume36
Issue number7
DOIs
StatePublished - Apr 2019
Externally publishedYes

Fingerprint

Atlases
Temporal Bone
Skull Base
Swine
Tomography
Research
Brain Injuries
Anatomy
Ear Canal
Mastoid
Cone-Beam Computed Tomography
Cochlea
Facial Nerve
Wounds and Injuries
Middle Ear
Inner Ear
Traumatic Brain Injury
Animal Models
Morbidity
Mortality

Keywords

  • brain injury
  • cone beam CT
  • CT
  • porcine TB
  • traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

High resolution computed tomography atlas of the porcine temporal bone and skull base : Anatomical correlates for traumatic brain injury research. / Knoll, Renata M.; Reinshagen, Katherine L.; Barber, Samuel R.; Ghanad, Iman; Swanson, Randel; Smith, Douglas H.; Abdullah, Kalil G.; Jung, David H.; Remenschneider, Aaron K.; Kozin, Elliott D.

In: Journal of neurotrauma, Vol. 36, No. 7, 04.2019, p. 1029-1039.

Research output: Contribution to journalArticle

Knoll, RM, Reinshagen, KL, Barber, SR, Ghanad, I, Swanson, R, Smith, DH, Abdullah, KG, Jung, DH, Remenschneider, AK & Kozin, ED 2019, 'High resolution computed tomography atlas of the porcine temporal bone and skull base: Anatomical correlates for traumatic brain injury research', Journal of neurotrauma, vol. 36, no. 7, pp. 1029-1039. https://doi.org/10.1089/neu.2018.5808
Knoll, Renata M. ; Reinshagen, Katherine L. ; Barber, Samuel R. ; Ghanad, Iman ; Swanson, Randel ; Smith, Douglas H. ; Abdullah, Kalil G. ; Jung, David H. ; Remenschneider, Aaron K. ; Kozin, Elliott D. / High resolution computed tomography atlas of the porcine temporal bone and skull base : Anatomical correlates for traumatic brain injury research. In: Journal of neurotrauma. 2019 ; Vol. 36, No. 7. pp. 1029-1039.
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