High risk breast lesions identified on MrI-guided vacuum-assisted needle biopsy: Outcome of surgical excision and imaging follow-up

Megan E. Speer, Monica L. Huang, Basak E. Dogan, Beatriz E. Adrada, Rosalind P. Candelaria, Kenneth R. Hess, Palita Hansakul, Wei T. Yang, Gaiane M. Rauch

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective: To determine whether breast MRI-guided vacuum-assisted biopsy (MRI-VAB) high-risk lesion histology influences surgical or long-term imaging follow-up outcomes. Methods: Patients with imaging-concordant high-risk findings on 9-gauge breast MRI-VAB between January 2007 and July 2012 who had surgical histopathology or 2 year imaging follow-up were retrospectively reviewed. results: 90 patients with 99 lesions were included. Lesions were atypical ductal hyperplasia (ADH) (n = 21), lobular neoplasia [n = 36; atypical lobular hyperplasia (ALH) (n = 22), lobular carcinoma in situ (LCIS) (n = 6), and ALH plus LCIS (n = 8)], and other high-risk lesion (n = 42; papillary lesions, radial scar, flat epithelial atypia, atypia unspecified). Of 53 excised lesions, 6 (11%) were upgraded to invasive cancer or ductal carcinoma in situ (DCIS). 4 of 21 (19%) ADH lesions were upgraded to DCIS. 2 of 36 (6%) lobular neoplasia lesions, both combined ALH and LCIS, were upgraded to DCIS, and invasive lobular carcinoma, respectively. The remaining 46 lesions were managed conservatively with imaging follow-up: 17 (37%) had mammography only, while 29 (63%) had mammography and MRI follow-up. There was no evidence of breast cancer development at the site of MRI-VAB in the cases with only imaging follow-up. conclusion: We conclude that the upgrade rate for high-risk lesions at MRI-VAB at surgical excision is low. Surgical excision is warranted for ADH and combined ALH-LCIS lesions. For other lesions, a multidisciplinary approach to decide on personalized management may be appropriate. advances in knowledge: Surgical excision is warranted for ADH lesions and combined ALH-LCIS lesions identified at breast MRI-VAB. A multidisciplinary approach to patient management of other high-risk lesions may be appropriate.

Original languageEnglish (US)
Article number20180300
JournalBritish Journal of Radiology
Volume91
Issue number1090
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Speer, M. E., Huang, M. L., Dogan, B. E., Adrada, B. E., Candelaria, R. P., Hess, K. R., Hansakul, P., Yang, W. T., & Rauch, G. M. (2018). High risk breast lesions identified on MrI-guided vacuum-assisted needle biopsy: Outcome of surgical excision and imaging follow-up. British Journal of Radiology, 91(1090), [20180300]. https://doi.org/10.1259/bjr.20180300