High risk of ventricular arrhythmias in patients with nonischemic dilated cardiomyopathy presenting with syncope

Robert S. Phang, David Kang, Hocine Tighiouart, N. A M Estes, Mark S. Link

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

It is not entirely clear whether the presentation of syncope in patients with nonischemic dilated cardiomyopathy (NIDC) is an ominous prognostic indicator, because randomized controlled implantable cardioverter-defibrillator (ICD) trials generally exclude such patients. This study compared 108 consecutive patients with NIDC presenting with syncope with 71 consecutive patients with NIDC who presented with sustained ventricular arrhythmias, with regard to freedom from any ventricular arrhythmias or life-threatening arrhythmias and all-cause mortality. There was no significant difference between the groups in the 3 outcomes during the follow-up of 43.5 ± 32.1 months. Male gender and ICD therapy predicted increased risk for any ventricular arrhythmias. A reduced left ventricular ejection fraction and increased age were predictive of increased mortality. In conclusion, patients with NIDC presenting with syncope are a high-risk group, with event rates similar to patients with NIDC presenting with sustained arrhythmias, and should be considered for ICD therapy.

Original languageEnglish (US)
Pages (from-to)416-420
Number of pages5
JournalAmerican Journal of Cardiology
Volume97
Issue number3
DOIs
StatePublished - Feb 1 2006

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Dilated Cardiomyopathy
Syncope
Cardiac Arrhythmias
Implantable Defibrillators
Mortality
Stroke Volume
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

High risk of ventricular arrhythmias in patients with nonischemic dilated cardiomyopathy presenting with syncope. / Phang, Robert S.; Kang, David; Tighiouart, Hocine; Estes, N. A M; Link, Mark S.

In: American Journal of Cardiology, Vol. 97, No. 3, 01.02.2006, p. 416-420.

Research output: Contribution to journalArticle

Phang, Robert S. ; Kang, David ; Tighiouart, Hocine ; Estes, N. A M ; Link, Mark S. / High risk of ventricular arrhythmias in patients with nonischemic dilated cardiomyopathy presenting with syncope. In: American Journal of Cardiology. 2006 ; Vol. 97, No. 3. pp. 416-420.
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