High risk of ventricular arrhythmias in patients with nonischemic dilated cardiomyopathy presenting with syncope

Robert S. Phang, David Kang, Hocine Tighiouart, N. A M Estes, Mark S. Link

Research output: Contribution to journalArticle

17 Scopus citations


It is not entirely clear whether the presentation of syncope in patients with nonischemic dilated cardiomyopathy (NIDC) is an ominous prognostic indicator, because randomized controlled implantable cardioverter-defibrillator (ICD) trials generally exclude such patients. This study compared 108 consecutive patients with NIDC presenting with syncope with 71 consecutive patients with NIDC who presented with sustained ventricular arrhythmias, with regard to freedom from any ventricular arrhythmias or life-threatening arrhythmias and all-cause mortality. There was no significant difference between the groups in the 3 outcomes during the follow-up of 43.5 ± 32.1 months. Male gender and ICD therapy predicted increased risk for any ventricular arrhythmias. A reduced left ventricular ejection fraction and increased age were predictive of increased mortality. In conclusion, patients with NIDC presenting with syncope are a high-risk group, with event rates similar to patients with NIDC presenting with sustained arrhythmias, and should be considered for ICD therapy.

Original languageEnglish (US)
Pages (from-to)416-420
Number of pages5
JournalAmerican Journal of Cardiology
Issue number3
Publication statusPublished - Feb 1 2006


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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