High-risk populations identified in childhood cancer survivor study investigations

Implications for risk-based surveillance

Melissa M. Hudson, Daniel A. Mulrooney, Daniel C. Bowers, Charles A. Sklar, Daniel M. Green, Sarah S. Donaldson, Kevin C. Oeffinger, Joseph P. Neglia, Anna T. Meadows, Leslie L. Robison

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Childhood cancer survivors often experience complications related to cancer and its treatment that may adversely affect quality of life and increase the risk of premature death. The purpose of this manuscript is to review how data derived from Childhood Cancer Survivor Study (CCSS) investigations have facilitated identification of childhood cancer survivor populations at high risk for specific organ toxicity and secondary carcinogenesis and how this has informed clinical screening practices. Articles previously published that used the resource of the CCSS to identify risk factors for specific organ toxicity and subsequent cancers were reviewed and results summarized. CCSS investigations have characterized specific groups to be at highest risk of morbidity related to endocrine and reproductive dysfunction, pulmonary toxicity, cerebrovascular injury, neurologic and neurosensory sequelae, and subsequent neoplasms. Factors influencing risk for specific outcomes related to the individual survivor (eg, sex, race/ethnicity, age at diagnosis, attained age), sociodemographic status (eg, education, household income, health insurance) and cancer history (eg, diagnosis, treatment, time from diagnosis) have been consistently identified. These CCSS investigations that clarify risk for treatment complications related to specific treatment modalities, cumulative dose exposures, and sociodemographic factors identify profiles of survivors at high risk for cancer-related morbidity who deserve heightened surveillance to optimize outcomes after treatment for childhood cancer.

Original languageEnglish (US)
Pages (from-to)2405-2414
Number of pages10
JournalJournal of Clinical Oncology
Volume27
Issue number14
DOIs
StatePublished - May 10 2009

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Survivors
Population
Neoplasms
Morbidity
Premature Mortality
Therapeutics
Health Insurance
Nervous System
Carcinogenesis
Quality of Life
Education
Lung
Wounds and Injuries

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

High-risk populations identified in childhood cancer survivor study investigations : Implications for risk-based surveillance. / Hudson, Melissa M.; Mulrooney, Daniel A.; Bowers, Daniel C.; Sklar, Charles A.; Green, Daniel M.; Donaldson, Sarah S.; Oeffinger, Kevin C.; Neglia, Joseph P.; Meadows, Anna T.; Robison, Leslie L.

In: Journal of Clinical Oncology, Vol. 27, No. 14, 10.05.2009, p. 2405-2414.

Research output: Contribution to journalArticle

Hudson, MM, Mulrooney, DA, Bowers, DC, Sklar, CA, Green, DM, Donaldson, SS, Oeffinger, KC, Neglia, JP, Meadows, AT & Robison, LL 2009, 'High-risk populations identified in childhood cancer survivor study investigations: Implications for risk-based surveillance', Journal of Clinical Oncology, vol. 27, no. 14, pp. 2405-2414. https://doi.org/10.1200/JCO.2008.21.1516
Hudson, Melissa M. ; Mulrooney, Daniel A. ; Bowers, Daniel C. ; Sklar, Charles A. ; Green, Daniel M. ; Donaldson, Sarah S. ; Oeffinger, Kevin C. ; Neglia, Joseph P. ; Meadows, Anna T. ; Robison, Leslie L. / High-risk populations identified in childhood cancer survivor study investigations : Implications for risk-based surveillance. In: Journal of Clinical Oncology. 2009 ; Vol. 27, No. 14. pp. 2405-2414.
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