High-risk subgroups of patients with non-Q wave myocardial infarction based on direction and severity of ST segment deviation

Stefan N. Willich, Peter H. Stone, James E. Muller, Geoffrey H. Tofler, James Crowder, Corette Parker, John D. Rutherford, Zoltan G. Turi, Thomas Robertson, Eugene Passamani, Eugene Braunwald

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Abstract

To determine the significance of the direction of ST segment deviation on admission of patients who evolved non-Q wave myocardial infarction (MI), 97 patients with initial ST segment depression were compared to 207 patients with initial ST segment elevation. Patients with ST segment depression developed smaller infarcts than those with ST segment elevation (creatine kinase MB isoenzyme 8.2 vs 13.3 gmEq/m2, p < 0.002), but had a lower left ventricular ejection fraction on admission (44% vs 51%, p < 0.001), more in-hospital complications, and a higher cumulative 1-year mortality (29% vs 11%, p < 0.001) that could be accounted for by an excess of adverse baseline characteristics. Although a severity index (combining magnitude and extent of the initial ST segment deviation) was not useful for discriminating prognosis of patients with non-Q wave MI who presented with ST segment depression, it was useful in identifying a subgroup of patients with ST segment elevation with an adverse prognosis. The poor outcome of patients with non-Q wave MI presenting with either ST segment depression or severe ST segment elevation on admission suggests that patients in these subgroups should receive close surveillance and should possibly be considered for aggressive therapy.

Original languageEnglish (US)
Pages (from-to)1110-1119
Number of pages10
JournalAmerican Heart Journal
Volume114
Issue number5
DOIs
StatePublished - 1987

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Myocardial Infarction
Patient Admission
MB Form Creatine Kinase
Stroke Volume
Isoenzymes
Direction compound
Mortality
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Willich, S. N., Stone, P. H., Muller, J. E., Tofler, G. H., Crowder, J., Parker, C., ... Braunwald, E. (1987). High-risk subgroups of patients with non-Q wave myocardial infarction based on direction and severity of ST segment deviation. American Heart Journal, 114(5), 1110-1119. https://doi.org/10.1016/0002-8703(87)90186-4

High-risk subgroups of patients with non-Q wave myocardial infarction based on direction and severity of ST segment deviation. / Willich, Stefan N.; Stone, Peter H.; Muller, James E.; Tofler, Geoffrey H.; Crowder, James; Parker, Corette; Rutherford, John D.; Turi, Zoltan G.; Robertson, Thomas; Passamani, Eugene; Braunwald, Eugene.

In: American Heart Journal, Vol. 114, No. 5, 1987, p. 1110-1119.

Research output: Contribution to journalArticle

Willich, SN, Stone, PH, Muller, JE, Tofler, GH, Crowder, J, Parker, C, Rutherford, JD, Turi, ZG, Robertson, T, Passamani, E & Braunwald, E 1987, 'High-risk subgroups of patients with non-Q wave myocardial infarction based on direction and severity of ST segment deviation', American Heart Journal, vol. 114, no. 5, pp. 1110-1119. https://doi.org/10.1016/0002-8703(87)90186-4
Willich, Stefan N. ; Stone, Peter H. ; Muller, James E. ; Tofler, Geoffrey H. ; Crowder, James ; Parker, Corette ; Rutherford, John D. ; Turi, Zoltan G. ; Robertson, Thomas ; Passamani, Eugene ; Braunwald, Eugene. / High-risk subgroups of patients with non-Q wave myocardial infarction based on direction and severity of ST segment deviation. In: American Heart Journal. 1987 ; Vol. 114, No. 5. pp. 1110-1119.
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