High speed phase distortion measurement and compensation for focusing in space and time

Reto Fiolka, Meng Cui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Random scattering and aberrations severely limit the imaging depth in optical microscopy. We introduce a rapid, parallel wavefront compensation technique that efficiently compensates even highly complex phase distortions. Using coherence gated backscattered light as a feedback signal, we focus light deep inside highly scattering brain tissue. We demonstrate that the same wavefront optimization technique can also be used to compensate spectral phase distortions in ultrashort laser pulses using nonlinear iterative feedback. We can restore transform limited pulse durations at any selected target location and compensate for dispersion that has occurred in the optical train and within the sample.

Original languageEnglish (US)
Title of host publicationThree-Dimensional and Multidimensional Microscopy
Subtitle of host publicationImage Acquisition and Processing XX
DOIs
StatePublished - May 28 2013
EventThree-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XX - San Francisco, CA, United States
Duration: Feb 5 2013Feb 7 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8589
ISSN (Print)1605-7422

Other

OtherThree-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XX
CountryUnited States
CitySan Francisco, CA
Period2/5/132/7/13

Keywords

  • Fluorescence microscopy
  • adaptive optics
  • imaging through turbid media
  • ultrafast optics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'High speed phase distortion measurement and compensation for focusing in space and time'. Together they form a unique fingerprint.

  • Cite this

    Fiolka, R., & Cui, M. (2013). High speed phase distortion measurement and compensation for focusing in space and time. In Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XX [85890V] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8589). https://doi.org/10.1117/12.2001121