High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma

Yi Ru Wu, Yi Chen Lee, Wei Ming Li, Wei Chi Hsu, Hui Hui Lin, Lin Li Chang, A. Mei Huang, Jhen Hao Jhan, Wen Jeng Wu, Ching Chia Li, Hsiang Ying Lee, Hsin Chih Yeh, Hung Lung Ke

Research output: Contribution to journalArticlepeer-review

Abstract

Upper tract urothelial carcinoma (UTUC) is a rare tumor with an incidence that varies greatly between Eastern and Western countries. Transaldolase 1 (TALDO1) is a rate-limiting enzyme of the pentose phosphate pathway. In humans, aberrant TALDO1 activity has been implicated in various autoimmune diseases and malignancies; however, the function of TALDO1 in UTUC has not been previously investigated. Here we evaluated the clinical significance of TALDO1 expression in 115 paraffin-embedded tumor samples from patients with UTUC using immunohistochemistry. Our results demonstrated that there was an association between high TALDO1 expression and advanced stage (P = 0.011), tumor size (P = 0.005), tumor location (P = 0.047), distant metastases (P = 0.023), local recurrence (P = 0.002), and cancer death (P = 0.003). Using univariate and multivariate analyses, we found that chemotherapy was an independent factor for bladder recurrence-free survival. Late stage (III/IV) and high TALDO1 expression were independent prognostic factors for progression-free and cancer-specific survival. In summary, increased TALDO1 expression in UTUC was significantly correlated with late stage, tumor size, tumor location, distant metastases, local recurrence, and cancer death. Therefore, high TALDO1 expression could be a predictor of poor survival in patients with UTUC. Further studies are necessary to investigate the role of TALDO1 in UTUC development.

Original languageEnglish (US)
JournalPathology International
DOIs
StateAccepted/In press - 2021

Keywords

  • Transaldolase 1
  • immunohistochemistry
  • prognosis
  • upper tract urothelial carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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