Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women

Carson C. Chow, Vipul Periwal, Gyorgy Csako, Madia Ricks, Amber B. Courville, Bernard V. Miller, Gloria L. Vega, Anne E. Sumner

Research output: Contribution to journalArticle

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Abstract

Context: Obesity and diabetes are more common in African-Americans than whites. Because free fatty acids (FFA) participate in the development of these conditions, studying race differences in the regulation of FFA and glucose by insulin is essential. Objective: The objective of the study was to determine whether race differences exist in glucose and FFA response to insulin. Design: This was a cross-sectional study. Setting: The study was conducted at a clinical research center. Participants: Thirty-four premenopausal women (17 African-Americans, 17 whites) matched for age [36 ± 10 yr (mean ± SD)] and body mass index (30.0 ± 6.7 kg/m 2). Interventions: Insulin-modified frequently sampled iv glucose tolerance tests were performed with data analyzed by separate minimal models for glucose and FFA. Main Outcome Measures: Glucose measures were insulin sensitivity index (S I) and acute insulin response to glucose (AIRg). FFA measures were FFA clearance rate (c f). Results: Body mass index was similar but fat mass was higher in African-Americans than whites (P <0.01). Compared with whites, African-Americans had lower SI (3.71 ± 1.55 vs. 5.23 ± 2.74 [×10 -4 min -1/(microunits per milliliter)] (P = 0.05) and higher AIRg (642 ± 379 vs. 263 ± 206 mU/liter -1 · min, P < 0.01). Adjusting for fat mass, African-Americans had higher FFA clearance, c f (0.13 ± 0.06 vs. 0.08 ± 0.05 min -1, P < 0.01). After adjusting for AIRg, the race difference in cf was no longer present (P = 0.51). For all women, the relationship between c f and AIRg was significant (r = -0.64, P < 0.01), but the relationship between c f and S I was not (r = -0.07, P = 0.71). The same pattern persisted when the two groups were studied separately. Conclusion: African-Americanwomenwere more insulin resistant than white women, yet they had greater FFA clearance. Acutely higher insulin concentrations in African-American women accounted for higher FFA clearance.

Original languageEnglish (US)
Pages (from-to)2456-2463
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number8
DOIs
StatePublished - Aug 2011

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Nonesterified Fatty Acids
African Americans
Insulin
Glucose
Body Mass Index
Fats
Hazards and race conditions
Glucose Tolerance Test
Medical problems
Insulin Resistance
Obesity
Cross-Sectional Studies
Outcome Assessment (Health Care)
Research

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women. / Chow, Carson C.; Periwal, Vipul; Csako, Gyorgy; Ricks, Madia; Courville, Amber B.; Miller, Bernard V.; Vega, Gloria L.; Sumner, Anne E.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 8, 08.2011, p. 2456-2463.

Research output: Contribution to journalArticle

Chow, Carson C. ; Periwal, Vipul ; Csako, Gyorgy ; Ricks, Madia ; Courville, Amber B. ; Miller, Bernard V. ; Vega, Gloria L. ; Sumner, Anne E. / Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women. In: Journal of Clinical Endocrinology and Metabolism. 2011 ; Vol. 96, No. 8. pp. 2456-2463.
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abstract = "Context: Obesity and diabetes are more common in African-Americans than whites. Because free fatty acids (FFA) participate in the development of these conditions, studying race differences in the regulation of FFA and glucose by insulin is essential. Objective: The objective of the study was to determine whether race differences exist in glucose and FFA response to insulin. Design: This was a cross-sectional study. Setting: The study was conducted at a clinical research center. Participants: Thirty-four premenopausal women (17 African-Americans, 17 whites) matched for age [36 ± 10 yr (mean ± SD)] and body mass index (30.0 ± 6.7 kg/m 2). Interventions: Insulin-modified frequently sampled iv glucose tolerance tests were performed with data analyzed by separate minimal models for glucose and FFA. Main Outcome Measures: Glucose measures were insulin sensitivity index (S I) and acute insulin response to glucose (AIRg). FFA measures were FFA clearance rate (c f). Results: Body mass index was similar but fat mass was higher in African-Americans than whites (P <0.01). Compared with whites, African-Americans had lower SI (3.71 ± 1.55 vs. 5.23 ± 2.74 [×10 -4 min -1/(microunits per milliliter)] (P = 0.05) and higher AIRg (642 ± 379 vs. 263 ± 206 mU/liter -1 · min, P < 0.01). Adjusting for fat mass, African-Americans had higher FFA clearance, c f (0.13 ± 0.06 vs. 0.08 ± 0.05 min -1, P < 0.01). After adjusting for AIRg, the race difference in cf was no longer present (P = 0.51). For all women, the relationship between c f and AIRg was significant (r = -0.64, P < 0.01), but the relationship between c f and S I was not (r = -0.07, P = 0.71). The same pattern persisted when the two groups were studied separately. Conclusion: African-Americanwomenwere more insulin resistant than white women, yet they had greater FFA clearance. Acutely higher insulin concentrations in African-American women accounted for higher FFA clearance.",
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AU - Periwal, Vipul

AU - Csako, Gyorgy

AU - Ricks, Madia

AU - Courville, Amber B.

AU - Miller, Bernard V.

AU - Vega, Gloria L.

AU - Sumner, Anne E.

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