Higher platelet distribution width predicts poor prognosis in laryngeal cancer

Huan Zhang, Li Liu, Shuang Fu, Yan Song Liu, Changsong Wang, Tiemin Liu, Zhi Ping Liu, Rui Tao Wang, Kai Jiang Yu

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Background: Activated platelets promote cancer progression and metastasis. However, the prognostic value of platelet indices in laryngeal cancer remains poorly understood. The purpose of this study was to investigate the predictive significance of platelet indices in laryngeal cancer. Results: Of the 241 patients, high platelet distribution width (PDW) levels were observed in 116 (48.1 %) patients. In the Kaplan-Meier analysis, increased PDW was significantly associated with a poorer overall survival (p < 0.001). In the multivariate Cox model, PDW was an independent prognostic index for overall survival (HR=4.381, 95% CI=2.313-8.298, P < 0.001). Method: The retrospective study included 241 consecutive patients with laryngeal cancer between January 2009 and December 2009. The relationships between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Conclusions: Elevated PDW might be a novel prognostic marker in laryngeal cancer.

Original languageEnglish (US)
Pages (from-to)48138-48144
Number of pages7
JournalOncotarget
Volume8
Issue number29
DOIs
StatePublished - Jan 1 2017

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Keywords

  • Laryngeal cancer
  • Platelet distribution width
  • Prognosis
  • Survival

ASJC Scopus subject areas

  • Oncology

Cite this

Zhang, H., Liu, L., Fu, S., Liu, Y. S., Wang, C., Liu, T., Liu, Z. P., Wang, R. T., & Yu, K. J. (2017). Higher platelet distribution width predicts poor prognosis in laryngeal cancer. Oncotarget, 8(29), 48138-48144. https://doi.org/10.18632/oncotarget.18306