Highly Aggressive Lymphomas in Adults

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Highly aggressive lymphomas are relatively uncommon in adults, comprising approximately 4% to 5% of all non-Hodgkin lymphomas in the United States and Western Europe. The designation of "highly aggressive" is generally restricted to precursor T-cell and B-cell lymphoblastic lymphoma/leukemia and Burkitt's lymphoma/leukemia. Treatment strategies for lymphoblastic lymphoma and Burkitt's lymphoma include complex, highly intensive combination chemotherapy regimens, which may be curative. As with other subtypes of NHL, emerging data from gene-expression profiling and related techniques are helping to define these entities more precisely and identify potential new rational therapeutic targets.

Original languageEnglish (US)
Pages (from-to)965-978
Number of pages14
JournalHematology/Oncology Clinics of North America
Volume22
Issue number5
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

Keywords

  • Burkitt
  • Burkitt-like
  • Lymphoblastic

ASJC Scopus subject areas

  • Hematology
  • Oncology

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