Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer

Yu Cheng, Anna C. Samia, Joseph D. Meyers, Irene Panagopoulos, Baowei Fei, Clemens Burda

Research output: Contribution to journalArticle

552 Citations (Scopus)

Abstract

A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.

Original languageEnglish (US)
Pages (from-to)10643-10647
Number of pages5
JournalJournal of the American Chemical Society
Volume130
Issue number32
DOIs
StatePublished - Aug 13 2008
Externally publishedYes

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Photodynamic therapy
Photochemotherapy
Drug delivery
Gold
Nanoparticles
Bearings (structural)
Pharmaceutical Preparations
Neoplasms
Tumors
Water

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer. / Cheng, Yu; Samia, Anna C.; Meyers, Joseph D.; Panagopoulos, Irene; Fei, Baowei; Burda, Clemens.

In: Journal of the American Chemical Society, Vol. 130, No. 32, 13.08.2008, p. 10643-10647.

Research output: Contribution to journalArticle

Cheng, Yu ; Samia, Anna C. ; Meyers, Joseph D. ; Panagopoulos, Irene ; Fei, Baowei ; Burda, Clemens. / Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer. In: Journal of the American Chemical Society. 2008 ; Vol. 130, No. 32. pp. 10643-10647.
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