Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer

Yu Cheng; Anna C. Samia; Joseph D. Meyers; Irene Panagopoulos; Baowei Fei; Clemens Burda

doi:10.1021/ja801631c

Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer

Yu Cheng, Anna C. Samia, Joseph D. Meyers, Irene Panagopoulos, Baowei Fei, Clemens Burda

Research output: Contribution to journal › Article › peer-review

680 Scopus citations

Abstract

A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.

Original language	English (US)
Pages (from-to)	10643-10647
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	130
Issue number	32
DOIs	https://doi.org/10.1021/ja801631c
State	Published - Aug 13 2008
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja801631c

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abstract = "A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible {"}cage{"} that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.",

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AU - Cheng, Yu

AU - Samia, Anna C.

AU - Meyers, Joseph D.

AU - Panagopoulos, Irene

AU - Fei, Baowei

AU - Burda, Clemens

PY - 2008/8/13

Y1 - 2008/8/13

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AB - A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.

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Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer

Abstract

ASJC Scopus subject areas

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