Hijacking of host cell IKK signalosomes by the transforming parasite Theileria

Volker T. Heussler, Sven Rottenberg, Rebekka Schwab, Peter Küenzi, Paula C. Fernandez, Susan McKellar, Brian Shiels, Zhijian J. Chen, Kim Orth, David Wallach, Dirk A E Dobbelaere

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Parasites have evolved a plethora of mechanisms to ensure their propagation and evade antagonistic host responses. The intracellular protozoan parasite Theileria is the only eukaryote known to induce uncontrolled host cell proliferation. Survival of Theileria-transformed leukocytes depends strictly on constitutive nuclear factor kappa B (NF-κB) activity. We found that this was mediated by recruitment of the muttisubunit IKB kinase (IKK) into large, activated foci on the parasite surface. IKK signatosome assembly was specific for the transforming schizont stage of the parasite and was down-regulated upon differentiation into the nontransforming merozoite stage. Our findings provide insights into IKK activation and how pathogens subvert host-cell signaling pathways.

Original languageEnglish (US)
Pages (from-to)1033-1036
Number of pages4
JournalScience
Volume298
Issue number5595
DOIs
StatePublished - Nov 1 2002

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Theileria
Parasites
Phosphotransferases
Schizonts
Merozoites
NF-kappa B
Eukaryota
Leukocytes
Cell Proliferation

ASJC Scopus subject areas

  • General

Cite this

Heussler, V. T., Rottenberg, S., Schwab, R., Küenzi, P., Fernandez, P. C., McKellar, S., ... Dobbelaere, D. A. E. (2002). Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. Science, 298(5595), 1033-1036. https://doi.org/10.1126/science.1075462

Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. / Heussler, Volker T.; Rottenberg, Sven; Schwab, Rebekka; Küenzi, Peter; Fernandez, Paula C.; McKellar, Susan; Shiels, Brian; Chen, Zhijian J.; Orth, Kim; Wallach, David; Dobbelaere, Dirk A E.

In: Science, Vol. 298, No. 5595, 01.11.2002, p. 1033-1036.

Research output: Contribution to journalArticle

Heussler, VT, Rottenberg, S, Schwab, R, Küenzi, P, Fernandez, PC, McKellar, S, Shiels, B, Chen, ZJ, Orth, K, Wallach, D & Dobbelaere, DAE 2002, 'Hijacking of host cell IKK signalosomes by the transforming parasite Theileria', Science, vol. 298, no. 5595, pp. 1033-1036. https://doi.org/10.1126/science.1075462
Heussler VT, Rottenberg S, Schwab R, Küenzi P, Fernandez PC, McKellar S et al. Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. Science. 2002 Nov 1;298(5595):1033-1036. https://doi.org/10.1126/science.1075462
Heussler, Volker T. ; Rottenberg, Sven ; Schwab, Rebekka ; Küenzi, Peter ; Fernandez, Paula C. ; McKellar, Susan ; Shiels, Brian ; Chen, Zhijian J. ; Orth, Kim ; Wallach, David ; Dobbelaere, Dirk A E. / Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. In: Science. 2002 ; Vol. 298, No. 5595. pp. 1033-1036.
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