HIP1: Trafficking roles and regulation of tumorigenesis

Teresa S. Hyun, Theodora S. Ross

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

During recent years, alterations in proteins of the endocytic pathway have been associated with tumors. Disrupted regulation of the endocytic pathway is a relatively unstudied mechanism of tumorigenesis, which can concomitantly disrupt several different signaling pathways to affect growth, differentiation and survival. Several endocytic proteins have been identified, either as part of tumor-associated translocations or to have the ability to transform cells. Here, we summarize the information known about huntingtin interacting protein 1 (HIP1), an endocytic protein with transforming properties that is involved in a cancer-causing translocation and which is overexpressed in a variety of human cancers. We describe the known normal functions of HIP1 in endocytosis and receptor trafficking, the evidence for its role as an oncoprotein and how HIP1 might be altered to promote tumorigenesis.

Original languageEnglish (US)
Pages (from-to)194-199
Number of pages6
JournalTrends in Molecular Medicine
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2004

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ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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