TY - JOUR
T1 - HIP1
T2 - Trafficking roles and regulation of tumorigenesis
AU - Hyun, Teresa S.
AU - Ross, Theodora S.
N1 - Funding Information:
We thank Katherine I. Oravecz-Wilson, Gaelle Bougeard-Denoyelle, Dinesh S. Rao, Lina Li, Ikuko Mizukami, Sarah V. Bradley, Paul Nolan, Hanshi Sun and Anthony Munaco for critical review of this article. This work was supported by a University of Michigan Cancer Biology training grant (T.S.H.), the NIH/NCI and Damon Runyon foundation (T.S.R.).
PY - 2004/4/1
Y1 - 2004/4/1
N2 - During recent years, alterations in proteins of the endocytic pathway have been associated with tumors. Disrupted regulation of the endocytic pathway is a relatively unstudied mechanism of tumorigenesis, which can concomitantly disrupt several different signaling pathways to affect growth, differentiation and survival. Several endocytic proteins have been identified, either as part of tumor-associated translocations or to have the ability to transform cells. Here, we summarize the information known about huntingtin interacting protein 1 (HIP1), an endocytic protein with transforming properties that is involved in a cancer-causing translocation and which is overexpressed in a variety of human cancers. We describe the known normal functions of HIP1 in endocytosis and receptor trafficking, the evidence for its role as an oncoprotein and how HIP1 might be altered to promote tumorigenesis.
AB - During recent years, alterations in proteins of the endocytic pathway have been associated with tumors. Disrupted regulation of the endocytic pathway is a relatively unstudied mechanism of tumorigenesis, which can concomitantly disrupt several different signaling pathways to affect growth, differentiation and survival. Several endocytic proteins have been identified, either as part of tumor-associated translocations or to have the ability to transform cells. Here, we summarize the information known about huntingtin interacting protein 1 (HIP1), an endocytic protein with transforming properties that is involved in a cancer-causing translocation and which is overexpressed in a variety of human cancers. We describe the known normal functions of HIP1 in endocytosis and receptor trafficking, the evidence for its role as an oncoprotein and how HIP1 might be altered to promote tumorigenesis.
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U2 - 10.1016/j.molmed.2004.02.003
DO - 10.1016/j.molmed.2004.02.003
M3 - Review article
C2 - 15059611
AN - SCOPUS:1642587778
SN - 1471-4914
VL - 10
SP - 194
EP - 199
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 4
ER -