Hippo signaling pathway and organ size control

Lei Zhang, Tao Yue, Jin Jiang

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Initially discovered in Drosophila, the Hippo (Hpo) pathway has been recognized as a conserved signaling pathway that controls organ size during development by restricting cell growth and proliferation and by promoting apoptosis. In addition, abnormal activities of several Hpo pathway components have been implicated in human cancer. Here, we review the current understanding of the molecular and cellular basis of Hpo signaling in development and tumorigenesis, and discuss how the Hpo pathway integrates spatial and temporal signals to control tissue growth and organ size.

Original languageEnglish (US)
Pages (from-to)68-73
Number of pages6
JournalFly
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 2009

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Keywords

  • Fat
  • Hippo
  • Lats
  • Merlin
  • MST
  • NF2
  • TEAD
  • Wts
  • Yap
  • Yki

ASJC Scopus subject areas

  • Insect Science

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