TY - JOUR
T1 - Hippocampal volume is reduced in schizophrenia and schizoaffective disorder but not in psychotic bipolar i disorder demonstrated by both manual tracing and automated parcellation (FreeSurfer)
AU - Arnold, Sara J M
AU - Ivleva, Elena I.
AU - Gopal, Tejas A.
AU - Reddy, Anil P.
AU - Jeon-Slaughter, Haekyung
AU - Sacco, Carolyn B.
AU - Francis, Alan N.
AU - Tandon, Neeraj
AU - Bidesi, Anup S.
AU - Witte, Bradley
AU - Poudyal, Gaurav
AU - Pearlson, Godfrey D.
AU - Sweeney, John A.
AU - Clementz, Brett A.
AU - Keshavan, Matcheri S.
AU - Tamminga, Carol A.
N1 - Publisher Copyright:
© The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - This study examined hippocampal volume as a putative biomarker for psychotic illness in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) psychosis sample, contrasting manual tracing and semiautomated (FreeSurfer) region-of-interest outcomes. The study sample (n = 596) included probands with schizophrenia (SZ, n = 71), schizoaffective disorder (SAD, n = 70), and psychotic bipolar I disorder (BDP, n = 86); their first-degree relatives (SZ-Rel, n = 74; SAD-Rel, n = 62; BDP-Rel, n = 88); and healthy controls (HC, n = 145). Hippocampal volumes were derived from 3Tesla T1-weighted MPRAGE images using manual tracing/3DSlicer3.6.3 and semiautomated parcellation/FreeSurfer5.1,64bit. Volumetric outcomes from both methodologies were contrasted in HC and probands and relatives across the 3 diagnoses, using mixed-effect regression models (SAS9.3 Proc MIXED); Pearson correlations between manual tracing and FreeSurfer outcomes were computed. SZ (P =.0007-.02) and SAD (P =.003-.14) had lower hippocampal volumes compared with HC, whereas BDP showed normal volumes bilaterally (P =.18-.55). All relative groups had hippocampal volumes not different from controls (P =.12-.97) and higher than those observed in probands (P =.003-.09), except for FreeSurfer measures in bipolar probands vs relatives (P =.64-.99). Outcomes from manual tracing and FreeSurfer showed direct, moderate to strong, correlations (r =.51-.73, P <.05). These findings from a large psychosis sample support decreased hippocampal volume as a putative biomarker for schizophrenia and schizoaffective disorder, but not for psychotic bipolar I disorder, and may reflect a cumulative effect of divergent primary disease processes and/or lifetime medication use. Manual tracing and semiautomated parcellation regional volumetric approaches may provide useful outcomes for defining measurable biomarkers underlying severe mental illness.
AB - This study examined hippocampal volume as a putative biomarker for psychotic illness in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) psychosis sample, contrasting manual tracing and semiautomated (FreeSurfer) region-of-interest outcomes. The study sample (n = 596) included probands with schizophrenia (SZ, n = 71), schizoaffective disorder (SAD, n = 70), and psychotic bipolar I disorder (BDP, n = 86); their first-degree relatives (SZ-Rel, n = 74; SAD-Rel, n = 62; BDP-Rel, n = 88); and healthy controls (HC, n = 145). Hippocampal volumes were derived from 3Tesla T1-weighted MPRAGE images using manual tracing/3DSlicer3.6.3 and semiautomated parcellation/FreeSurfer5.1,64bit. Volumetric outcomes from both methodologies were contrasted in HC and probands and relatives across the 3 diagnoses, using mixed-effect regression models (SAS9.3 Proc MIXED); Pearson correlations between manual tracing and FreeSurfer outcomes were computed. SZ (P =.0007-.02) and SAD (P =.003-.14) had lower hippocampal volumes compared with HC, whereas BDP showed normal volumes bilaterally (P =.18-.55). All relative groups had hippocampal volumes not different from controls (P =.12-.97) and higher than those observed in probands (P =.003-.09), except for FreeSurfer measures in bipolar probands vs relatives (P =.64-.99). Outcomes from manual tracing and FreeSurfer showed direct, moderate to strong, correlations (r =.51-.73, P <.05). These findings from a large psychosis sample support decreased hippocampal volume as a putative biomarker for schizophrenia and schizoaffective disorder, but not for psychotic bipolar I disorder, and may reflect a cumulative effect of divergent primary disease processes and/or lifetime medication use. Manual tracing and semiautomated parcellation regional volumetric approaches may provide useful outcomes for defining measurable biomarkers underlying severe mental illness.
KW - FreeSurfer
KW - hippocampus
KW - manual tracing
KW - psychotic bipolar disorder
KW - schizophrenia
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U2 - 10.1093/schbul/sbu009
DO - 10.1093/schbul/sbu009
M3 - Article
C2 - 24557771
AN - SCOPUS:84961344393
SN - 0586-7614
VL - 41
SP - 233
EP - 249
JO - Schizophrenia bulletin
JF - Schizophrenia bulletin
IS - 1
ER -