Hippocampal volume is reduced in schizophrenia and schizoaffective disorder but not in psychotic bipolar i disorder demonstrated by both manual tracing and automated parcellation (FreeSurfer)

Sara J M Arnold, Elena I. Ivleva, Tejas A. Gopal, Anil P. Reddy, Haekyung Jeon-Slaughter, Carolyn B. Sacco, Alan N. Francis, Neeraj Tandon, Anup S. Bidesi, Bradley Witte, Gaurav Poudyal, Godfrey D. Pearlson, John A. Sweeney, Brett A. Clementz, Matcheri S. Keshavan, Carol A. Tamminga

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

This study examined hippocampal volume as a putative biomarker for psychotic illness in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) psychosis sample, contrasting manual tracing and semiautomated (FreeSurfer) region-of-interest outcomes. The study sample (n = 596) included probands with schizophrenia (SZ, n = 71), schizoaffective disorder (SAD, n = 70), and psychotic bipolar I disorder (BDP, n = 86); their first-degree relatives (SZ-Rel, n = 74; SAD-Rel, n = 62; BDP-Rel, n = 88); and healthy controls (HC, n = 145). Hippocampal volumes were derived from 3Tesla T1-weighted MPRAGE images using manual tracing/3DSlicer3.6.3 and semiautomated parcellation/FreeSurfer5.1,64bit. Volumetric outcomes from both methodologies were contrasted in HC and probands and relatives across the 3 diagnoses, using mixed-effect regression models (SAS9.3 Proc MIXED); Pearson correlations between manual tracing and FreeSurfer outcomes were computed. SZ (P =.0007-.02) and SAD (P =.003-.14) had lower hippocampal volumes compared with HC, whereas BDP showed normal volumes bilaterally (P =.18-.55). All relative groups had hippocampal volumes not different from controls (P =.12-.97) and higher than those observed in probands (P =.003-.09), except for FreeSurfer measures in bipolar probands vs relatives (P =.64-.99). Outcomes from manual tracing and FreeSurfer showed direct, moderate to strong, correlations (r =.51-.73, P

Original languageEnglish (US)
Pages (from-to)233-249
Number of pages17
JournalSchizophrenia Bulletin
Volume41
Issue number1
DOIs
StatePublished - Jan 1 2015

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Bipolar Disorder
Psychotic Disorders
Schizophrenia
Biomarkers
Phenotype

Keywords

  • FreeSurfer
  • hippocampus
  • manual tracing
  • psychotic bipolar disorder
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Hippocampal volume is reduced in schizophrenia and schizoaffective disorder but not in psychotic bipolar i disorder demonstrated by both manual tracing and automated parcellation (FreeSurfer). / Arnold, Sara J M; Ivleva, Elena I.; Gopal, Tejas A.; Reddy, Anil P.; Jeon-Slaughter, Haekyung; Sacco, Carolyn B.; Francis, Alan N.; Tandon, Neeraj; Bidesi, Anup S.; Witte, Bradley; Poudyal, Gaurav; Pearlson, Godfrey D.; Sweeney, John A.; Clementz, Brett A.; Keshavan, Matcheri S.; Tamminga, Carol A.

In: Schizophrenia Bulletin, Vol. 41, No. 1, 01.01.2015, p. 233-249.

Research output: Contribution to journalArticle

Arnold, SJM, Ivleva, EI, Gopal, TA, Reddy, AP, Jeon-Slaughter, H, Sacco, CB, Francis, AN, Tandon, N, Bidesi, AS, Witte, B, Poudyal, G, Pearlson, GD, Sweeney, JA, Clementz, BA, Keshavan, MS & Tamminga, CA 2015, 'Hippocampal volume is reduced in schizophrenia and schizoaffective disorder but not in psychotic bipolar i disorder demonstrated by both manual tracing and automated parcellation (FreeSurfer)', Schizophrenia Bulletin, vol. 41, no. 1, pp. 233-249. https://doi.org/10.1093/schbul/sbu009
Arnold, Sara J M ; Ivleva, Elena I. ; Gopal, Tejas A. ; Reddy, Anil P. ; Jeon-Slaughter, Haekyung ; Sacco, Carolyn B. ; Francis, Alan N. ; Tandon, Neeraj ; Bidesi, Anup S. ; Witte, Bradley ; Poudyal, Gaurav ; Pearlson, Godfrey D. ; Sweeney, John A. ; Clementz, Brett A. ; Keshavan, Matcheri S. ; Tamminga, Carol A. / Hippocampal volume is reduced in schizophrenia and schizoaffective disorder but not in psychotic bipolar i disorder demonstrated by both manual tracing and automated parcellation (FreeSurfer). In: Schizophrenia Bulletin. 2015 ; Vol. 41, No. 1. pp. 233-249.
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