Histochemical analysis of mucous cells of congenital adenomatoid malformation of the lung: Insights into the carcinogenesis of pulmonary adenocarcinoma expressing gastric mucins

Hiroyoshi Ota, Claire Langston, Takayuki Honda, Tsutomu Katsuyama, Robert M. Genta

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Adenocarcinomas expressing gastric mucins often are accompanied by ectopic gastric mucosa or pyloric metaplasia. We have previously described mucinous bronchioloalveolar carcinoma (mucinous BAC) producing gastric mucins. In the lung tissue, mucous cells seemingly similar to gastric mucous cells are present in congenital adenomatoid malformation (CAM). We assessed 26 cases of CAM morphologically and histochemically. Mucous cells were detected in 12 of 26 cases. These mucous cells displayed papillary growth in cystic spaces and proliferated along alveolar walls. Mucous cells in the papillary configuration stained with galactose oxidase cold thionine Schiff reaction, and those in indented portions stained with paradoxical concanavalin A stain in all 8 cases and with pepsinogen II in 5 of 8 cases, which were available for histochemical analysis. Pepsinogen I was negative. Mucous cells in CAM were identical to those of pyloric mucosa and could be considered candidates for the origin of mucinous BAC producing gastric mucins.

Original languageEnglish (US)
Pages (from-to)450-455
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume110
Issue number4
StatePublished - Oct 1998

Fingerprint

Gastric Mucins
Carcinogenesis
Lung
Bronchiolo-Alveolar Adenocarcinoma
Mucinous Adenocarcinoma
Pepsinogen C
Galactose Oxidase
Pepsinogen A
Metaplasia
Concanavalin A
Gastric Mucosa
Adenocarcinoma of lung
Stomach
Mucous Membrane
Adenocarcinoma
Growth

Keywords

  • Congenital adenomatoid malformation
  • Gastric mucin
  • Immunohistochemistry
  • Mucinous bronchiolalveolar carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Histochemical analysis of mucous cells of congenital adenomatoid malformation of the lung : Insights into the carcinogenesis of pulmonary adenocarcinoma expressing gastric mucins. / Ota, Hiroyoshi; Langston, Claire; Honda, Takayuki; Katsuyama, Tsutomu; Genta, Robert M.

In: American Journal of Clinical Pathology, Vol. 110, No. 4, 10.1998, p. 450-455.

Research output: Contribution to journalArticle

@article{5251a2a57dbe4c53958a97365932a4c2,
title = "Histochemical analysis of mucous cells of congenital adenomatoid malformation of the lung: Insights into the carcinogenesis of pulmonary adenocarcinoma expressing gastric mucins",
abstract = "Adenocarcinomas expressing gastric mucins often are accompanied by ectopic gastric mucosa or pyloric metaplasia. We have previously described mucinous bronchioloalveolar carcinoma (mucinous BAC) producing gastric mucins. In the lung tissue, mucous cells seemingly similar to gastric mucous cells are present in congenital adenomatoid malformation (CAM). We assessed 26 cases of CAM morphologically and histochemically. Mucous cells were detected in 12 of 26 cases. These mucous cells displayed papillary growth in cystic spaces and proliferated along alveolar walls. Mucous cells in the papillary configuration stained with galactose oxidase cold thionine Schiff reaction, and those in indented portions stained with paradoxical concanavalin A stain in all 8 cases and with pepsinogen II in 5 of 8 cases, which were available for histochemical analysis. Pepsinogen I was negative. Mucous cells in CAM were identical to those of pyloric mucosa and could be considered candidates for the origin of mucinous BAC producing gastric mucins.",
keywords = "Congenital adenomatoid malformation, Gastric mucin, Immunohistochemistry, Mucinous bronchiolalveolar carcinoma",
author = "Hiroyoshi Ota and Claire Langston and Takayuki Honda and Tsutomu Katsuyama and Genta, {Robert M.}",
year = "1998",
month = "10",
language = "English (US)",
volume = "110",
pages = "450--455",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "4",

}

TY - JOUR

T1 - Histochemical analysis of mucous cells of congenital adenomatoid malformation of the lung

T2 - Insights into the carcinogenesis of pulmonary adenocarcinoma expressing gastric mucins

AU - Ota, Hiroyoshi

AU - Langston, Claire

AU - Honda, Takayuki

AU - Katsuyama, Tsutomu

AU - Genta, Robert M.

PY - 1998/10

Y1 - 1998/10

N2 - Adenocarcinomas expressing gastric mucins often are accompanied by ectopic gastric mucosa or pyloric metaplasia. We have previously described mucinous bronchioloalveolar carcinoma (mucinous BAC) producing gastric mucins. In the lung tissue, mucous cells seemingly similar to gastric mucous cells are present in congenital adenomatoid malformation (CAM). We assessed 26 cases of CAM morphologically and histochemically. Mucous cells were detected in 12 of 26 cases. These mucous cells displayed papillary growth in cystic spaces and proliferated along alveolar walls. Mucous cells in the papillary configuration stained with galactose oxidase cold thionine Schiff reaction, and those in indented portions stained with paradoxical concanavalin A stain in all 8 cases and with pepsinogen II in 5 of 8 cases, which were available for histochemical analysis. Pepsinogen I was negative. Mucous cells in CAM were identical to those of pyloric mucosa and could be considered candidates for the origin of mucinous BAC producing gastric mucins.

AB - Adenocarcinomas expressing gastric mucins often are accompanied by ectopic gastric mucosa or pyloric metaplasia. We have previously described mucinous bronchioloalveolar carcinoma (mucinous BAC) producing gastric mucins. In the lung tissue, mucous cells seemingly similar to gastric mucous cells are present in congenital adenomatoid malformation (CAM). We assessed 26 cases of CAM morphologically and histochemically. Mucous cells were detected in 12 of 26 cases. These mucous cells displayed papillary growth in cystic spaces and proliferated along alveolar walls. Mucous cells in the papillary configuration stained with galactose oxidase cold thionine Schiff reaction, and those in indented portions stained with paradoxical concanavalin A stain in all 8 cases and with pepsinogen II in 5 of 8 cases, which were available for histochemical analysis. Pepsinogen I was negative. Mucous cells in CAM were identical to those of pyloric mucosa and could be considered candidates for the origin of mucinous BAC producing gastric mucins.

KW - Congenital adenomatoid malformation

KW - Gastric mucin

KW - Immunohistochemistry

KW - Mucinous bronchiolalveolar carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0031663652&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031663652&partnerID=8YFLogxK

M3 - Article

C2 - 9763030

AN - SCOPUS:0031663652

VL - 110

SP - 450

EP - 455

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 4

ER -