Histocompatibility-2 system in wild mice. X. Frequencies of H-2 and Ia antigens in wild mice from Europe and Africa

D. Götze, J. Nadeau, E. K. Wakeland, R. J. Berry, F. Bonhomme, I. K. Egorov, J. P. Hjorth, H. Hoogstraal, J. Vives, H. Winking, J. Klein

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30 Scopus citations

Abstract

In this study, data are presented on serologic H-2 typing of 320 wild mice collected in several parts of Europe and Egypt. The sample was typed for 39 class I (K, D) and 16 class II (Ia) antigens. The phenotypic frequencies of class I and class II antigens showed high variability in their distribution among different areas, ranging from absence or presence in low frequency in one area to presence in about one-half of the mice in another area. The average phenotypic frequency of class I private antigens was 6.3%; at least 60% of class I alleles (blanks) could not be identified with the available reagents. The data suggest that there might be more than 100 alleles for each class I locus, H-2K and H-2D. The average phenotypic frequencies of Ia-1 private antigens was 10.8%. About 75% of Ia-1 alleles (blanks) could not be identified. The number of Ia-1 alleles was estimated to be in the range of 20 to 50.

Original languageEnglish (US)
Pages (from-to)2675-2681
Number of pages7
JournalJournal of Immunology
Volume124
Issue number6
StatePublished - Jul 18 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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