Histocompatibility antigen-activated cytotoxic T lymphocytes: I. Estimates of the absolute frequency of killer cells generated in vitro*

K. Fischer Lindahl, D. B. Wilson

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

A sensitive procedure employing limiting dilution of activated lymphocytes and 51Cr release from highly labeled target cells was used to derive minimal estimates of the absolute frequency of cytotoxic T lymphocytes (CTL) present in a population of mouse lymphocytes activated to alloantigens of the major histocompatibility complex in bulk mixed lymphocyte cultures. From this figure (0.7-1.2%), the maximal rate of target cell killing could be calculated to be approximately 4 targets/CTL/hour.

Original languageEnglish (US)
Pages (from-to)500-507
Number of pages8
JournalJournal of Experimental Medicine
Volume145
Issue number3
DOIs
StatePublished - Mar 1 1977

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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