Abstract
A sensitive procedure employing limiting dilution of activated lymphocytes and 51Cr release from highly labeled target cells was used to derive minimal estimates of the absolute frequency of cytotoxic T lymphocytes (CTL) present in a population of mouse lymphocytes activated to alloantigens of the major histocompatibility complex in bulk mixed lymphocyte cultures. From this figure (0.7-1.2%), the maximal rate of target cell killing could be calculated to be approximately 4 targets/CTL/hour.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 500-507 |
| Number of pages | 8 |
| Journal | Journal of Experimental Medicine |
| Volume | 145 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 1977 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Fischer Lindahl, K., & Wilson, D. B. (1977). Histocompatibility antigen-activated cytotoxic T lymphocytes: I. Estimates of the absolute frequency of killer cells generated in vitro*. Journal of Experimental Medicine, 145(3), 500-507. https://doi.org/10.1084/jem.145.3.500