Abstract
A sensitive procedure employing limiting dilution of activated lymphocytes and 51Cr release from highly labeled target cells was used to derive minimal estimates of the absolute frequency of cytotoxic T lymphocytes (CTL) present in a population of mouse lymphocytes activated to alloantigens of the major histocompatibility complex in bulk mixed lymphocyte cultures. From this figure (0.7-1.2%), the maximal rate of target cell killing could be calculated to be approximately 4 targets/CTL/hour.
Original language | English (US) |
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Pages (from-to) | 500-507 |
Number of pages | 8 |
Journal | Journal of Experimental Medicine |
Volume | 145 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 1977 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology