Histological diagnosis of Helicobacter pylori using biopsy specimens

Helicobacter pylori(H. pylori) are an organism that can be confidently recognized by histology. Using histological specimens, we can both identify infection and assess pathological condition associated with H. pylori. For the precise diagnosis, biopsies should be taken from suitable sites(greater curvature of antrum and corpus) and the valuable requirements are to recognize several pathologic findings of H. pylori--infected gastric mucosa(epithelial changes and neutrophilic infiltration together with mononuclear cell infiltration) and to use special staining methods for H. pylori(i.e. Giemsa staining, Gimenez staining, silver staining, and immunostaining) in addition to HE staining.