Histology of transplantable murine epithelial tumors infiltrated with immature T lymphocytes: Neoplastic analogues of the thymus

G. P. Hoot, F. A. Harrod, J. R. Kettman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Serially transplantable murine thymic and salivary gland epithelial tumors were studied by immunohistologic methods and by electron microscopy. At the ultrastructural level, tumors appear to be identical. The large polygonal epithelial cells lack rough endoplasmic reticulum, Golgi apparatus, and secretory vesicles, and are anchored together by tonofilaments and desmosome junctions. Some areas in the tumors are composed solely of the neoplastic epithelium, while other areas are richly 'infiltrated' with lymphocytes having a cortical thymocyte phenotype and supported by a lacy dendritic network of neoplastic epithelial cells. Immunohistochemical staining demonstrates that the epithelial cells express class I and class II major histocompatibility gene complex (MHC) antigens, epidermal keratin, and the ER-TR4 and ER-TR5 thymic epithelial markers. Lymphocyte-rich regions show homogeneous staining for both L3T4 (CD4) and Lyt-2 (CD8) T-cell antigens.

Original languageEnglish (US)
Pages (from-to)81-95
Number of pages15
JournalThymus
Volume17
Issue number2
StatePublished - 1991

Fingerprint

Thymus Gland
Histology
Epithelial Cells
T-Lymphocytes
Lymphocytes
Staining and Labeling
Neoplasms
Desmosomes
Intermediate Filaments
Rough Endoplasmic Reticulum
Viral Tumor Antigens
Secretory Vesicles
Golgi Apparatus
Thymocytes
Keratins
Salivary Glands
Major Histocompatibility Complex
Electron Microscopy
Epithelium
Phenotype

ASJC Scopus subject areas

  • Immunology

Cite this

Histology of transplantable murine epithelial tumors infiltrated with immature T lymphocytes : Neoplastic analogues of the thymus. / Hoot, G. P.; Harrod, F. A.; Kettman, J. R.

In: Thymus, Vol. 17, No. 2, 1991, p. 81-95.

Research output: Contribution to journalArticle

@article{6bedc9fbd7f94eb8bc7c20144fa8c4de,
title = "Histology of transplantable murine epithelial tumors infiltrated with immature T lymphocytes: Neoplastic analogues of the thymus",
abstract = "Serially transplantable murine thymic and salivary gland epithelial tumors were studied by immunohistologic methods and by electron microscopy. At the ultrastructural level, tumors appear to be identical. The large polygonal epithelial cells lack rough endoplasmic reticulum, Golgi apparatus, and secretory vesicles, and are anchored together by tonofilaments and desmosome junctions. Some areas in the tumors are composed solely of the neoplastic epithelium, while other areas are richly 'infiltrated' with lymphocytes having a cortical thymocyte phenotype and supported by a lacy dendritic network of neoplastic epithelial cells. Immunohistochemical staining demonstrates that the epithelial cells express class I and class II major histocompatibility gene complex (MHC) antigens, epidermal keratin, and the ER-TR4 and ER-TR5 thymic epithelial markers. Lymphocyte-rich regions show homogeneous staining for both L3T4 (CD4) and Lyt-2 (CD8) T-cell antigens.",
author = "Hoot, {G. P.} and Harrod, {F. A.} and Kettman, {J. R.}",
year = "1991",
language = "English (US)",
volume = "17",
pages = "81--95",
journal = "Thymus",
issn = "0165-6090",
publisher = "Kluwer Academic Publishers",
number = "2",

}

TY - JOUR

T1 - Histology of transplantable murine epithelial tumors infiltrated with immature T lymphocytes

T2 - Neoplastic analogues of the thymus

AU - Hoot, G. P.

AU - Harrod, F. A.

AU - Kettman, J. R.

PY - 1991

Y1 - 1991

N2 - Serially transplantable murine thymic and salivary gland epithelial tumors were studied by immunohistologic methods and by electron microscopy. At the ultrastructural level, tumors appear to be identical. The large polygonal epithelial cells lack rough endoplasmic reticulum, Golgi apparatus, and secretory vesicles, and are anchored together by tonofilaments and desmosome junctions. Some areas in the tumors are composed solely of the neoplastic epithelium, while other areas are richly 'infiltrated' with lymphocytes having a cortical thymocyte phenotype and supported by a lacy dendritic network of neoplastic epithelial cells. Immunohistochemical staining demonstrates that the epithelial cells express class I and class II major histocompatibility gene complex (MHC) antigens, epidermal keratin, and the ER-TR4 and ER-TR5 thymic epithelial markers. Lymphocyte-rich regions show homogeneous staining for both L3T4 (CD4) and Lyt-2 (CD8) T-cell antigens.

AB - Serially transplantable murine thymic and salivary gland epithelial tumors were studied by immunohistologic methods and by electron microscopy. At the ultrastructural level, tumors appear to be identical. The large polygonal epithelial cells lack rough endoplasmic reticulum, Golgi apparatus, and secretory vesicles, and are anchored together by tonofilaments and desmosome junctions. Some areas in the tumors are composed solely of the neoplastic epithelium, while other areas are richly 'infiltrated' with lymphocytes having a cortical thymocyte phenotype and supported by a lacy dendritic network of neoplastic epithelial cells. Immunohistochemical staining demonstrates that the epithelial cells express class I and class II major histocompatibility gene complex (MHC) antigens, epidermal keratin, and the ER-TR4 and ER-TR5 thymic epithelial markers. Lymphocyte-rich regions show homogeneous staining for both L3T4 (CD4) and Lyt-2 (CD8) T-cell antigens.

UR - http://www.scopus.com/inward/record.url?scp=0026101294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026101294&partnerID=8YFLogxK

M3 - Article

C2 - 2028510

AN - SCOPUS:0026101294

VL - 17

SP - 81

EP - 95

JO - Thymus

JF - Thymus

SN - 0165-6090

IS - 2

ER -