Histone chaperones in nucleosome assembly and human disease

Rebecca J. Burgess; Zhiguo Zhang

doi:10.1038/nsmb.2461

Histone chaperones in nucleosome assembly and human disease

Rebecca J. Burgess, Zhiguo Zhang

Research output: Contribution to journal › Review article › peer-review

282 Scopus citations

Abstract

Nucleosome assembly following DNA replication, DNA repair and gene transcription is critical for the maintenance of genome stability and epigenetic information. Nucleosomes are assembled by replication-coupled or replication-independent pathways with the aid of histone chaperone proteins. How these different nucleosome assembly pathways are regulated remains relatively unclear. Recent studies have provided insight into the mechanisms and the roles of histone chaperones in regulating nucleosome assembly. Alterations or mutations in factors involved in nucleosome assembly have also been implicated in cancer and other human diseases. This review highlights the recent progress and outlines future challenges in the field.

Original language	English (US)
Pages (from-to)	14-22
Number of pages	9
Journal	Nature Structural and Molecular Biology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1038/nsmb.2461
State	Published - Jan 2013
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1038/nsmb.2461

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title = "Histone chaperones in nucleosome assembly and human disease",

abstract = "Nucleosome assembly following DNA replication, DNA repair and gene transcription is critical for the maintenance of genome stability and epigenetic information. Nucleosomes are assembled by replication-coupled or replication-independent pathways with the aid of histone chaperone proteins. How these different nucleosome assembly pathways are regulated remains relatively unclear. Recent studies have provided insight into the mechanisms and the roles of histone chaperones in regulating nucleosome assembly. Alterations or mutations in factors involved in nucleosome assembly have also been implicated in cancer and other human diseases. This review highlights the recent progress and outlines future challenges in the field.",

author = "Burgess, {Rebecca J.} and Zhiguo Zhang",

note = "Funding Information: We apologize to those whose work could not cited in this review, owing to space limitations. We thank G. Mer for use of the Rtt106–(H3–H4)2 complex structural model coordinates. This work is supported by grants to Z.Z. from the US National Institutes of Health (GM72719, GM81838, GM99722) and the National Science Foundation of China (NSFC) Collaboration grant (31210103914). Z.Z. is supported as a scholar of the Leukemia and Lymphoma Society.",

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N2 - Nucleosome assembly following DNA replication, DNA repair and gene transcription is critical for the maintenance of genome stability and epigenetic information. Nucleosomes are assembled by replication-coupled or replication-independent pathways with the aid of histone chaperone proteins. How these different nucleosome assembly pathways are regulated remains relatively unclear. Recent studies have provided insight into the mechanisms and the roles of histone chaperones in regulating nucleosome assembly. Alterations or mutations in factors involved in nucleosome assembly have also been implicated in cancer and other human diseases. This review highlights the recent progress and outlines future challenges in the field.

AB - Nucleosome assembly following DNA replication, DNA repair and gene transcription is critical for the maintenance of genome stability and epigenetic information. Nucleosomes are assembled by replication-coupled or replication-independent pathways with the aid of histone chaperone proteins. How these different nucleosome assembly pathways are regulated remains relatively unclear. Recent studies have provided insight into the mechanisms and the roles of histone chaperones in regulating nucleosome assembly. Alterations or mutations in factors involved in nucleosome assembly have also been implicated in cancer and other human diseases. This review highlights the recent progress and outlines future challenges in the field.

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Histone chaperones in nucleosome assembly and human disease

Abstract

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