Histone deacetylase inhibitors and cell death

Jing Zhang, Qing Zhong

Research output: Contribution to journalReview article

87 Citations (Scopus)

Abstract

Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin remodeling and have crucial roles in numerous biological processes, largely through their repressive influence on transcription. In addition to modifying histones, HDACs also target many other non-histone protein substrates to regulate gene expression. Recently, HDACs have gained growing attention as HDAC-inhibiting compounds are being developed as promising cancer therapeutics. Histone deacetylase inhibitors (HDACi) have been shown to induce differentiation, cell cycle arrest, apoptosis, autophagy and necrosis in a variety of transformed cell lines. In this review, we mainly discuss how HDACi may elicit a therapeutic response to human cancers through different cell death pathways, in particular, apoptosis and autophagy.

Original languageEnglish (US)
Pages (from-to)3885-3901
Number of pages17
JournalCellular and Molecular Life Sciences
Volume71
Issue number20
DOIs
StatePublished - Oct 1 2014

Fingerprint

Histone Deacetylase Inhibitors
Histone Deacetylases
Cell Death
Autophagy
Apoptosis
Biological Phenomena
Transformed Cell Line
Chromatin Assembly and Disassembly
Cell Cycle Checkpoints
Histones
Neoplasms
Necrosis
Gene Expression
Enzymes
Therapeutics
Proteins

Keywords

  • Apoptosis
  • Autophagy
  • Cell death
  • Histone deacetylase inhibitor (HDACi)
  • Histone deacetylases (HDACs)

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Histone deacetylase inhibitors and cell death. / Zhang, Jing; Zhong, Qing.

In: Cellular and Molecular Life Sciences, Vol. 71, No. 20, 01.10.2014, p. 3885-3901.

Research output: Contribution to journalReview article

Zhang, Jing ; Zhong, Qing. / Histone deacetylase inhibitors and cell death. In: Cellular and Molecular Life Sciences. 2014 ; Vol. 71, No. 20. pp. 3885-3901.
@article{5cabf996726e446c87bd604e6dca980a,
title = "Histone deacetylase inhibitors and cell death",
abstract = "Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin remodeling and have crucial roles in numerous biological processes, largely through their repressive influence on transcription. In addition to modifying histones, HDACs also target many other non-histone protein substrates to regulate gene expression. Recently, HDACs have gained growing attention as HDAC-inhibiting compounds are being developed as promising cancer therapeutics. Histone deacetylase inhibitors (HDACi) have been shown to induce differentiation, cell cycle arrest, apoptosis, autophagy and necrosis in a variety of transformed cell lines. In this review, we mainly discuss how HDACi may elicit a therapeutic response to human cancers through different cell death pathways, in particular, apoptosis and autophagy.",
keywords = "Apoptosis, Autophagy, Cell death, Histone deacetylase inhibitor (HDACi), Histone deacetylases (HDACs)",
author = "Jing Zhang and Qing Zhong",
year = "2014",
month = "10",
day = "1",
doi = "10.1007/s00018-014-1656-6",
language = "English (US)",
volume = "71",
pages = "3885--3901",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "20",

}

TY - JOUR

T1 - Histone deacetylase inhibitors and cell death

AU - Zhang, Jing

AU - Zhong, Qing

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin remodeling and have crucial roles in numerous biological processes, largely through their repressive influence on transcription. In addition to modifying histones, HDACs also target many other non-histone protein substrates to regulate gene expression. Recently, HDACs have gained growing attention as HDAC-inhibiting compounds are being developed as promising cancer therapeutics. Histone deacetylase inhibitors (HDACi) have been shown to induce differentiation, cell cycle arrest, apoptosis, autophagy and necrosis in a variety of transformed cell lines. In this review, we mainly discuss how HDACi may elicit a therapeutic response to human cancers through different cell death pathways, in particular, apoptosis and autophagy.

AB - Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin remodeling and have crucial roles in numerous biological processes, largely through their repressive influence on transcription. In addition to modifying histones, HDACs also target many other non-histone protein substrates to regulate gene expression. Recently, HDACs have gained growing attention as HDAC-inhibiting compounds are being developed as promising cancer therapeutics. Histone deacetylase inhibitors (HDACi) have been shown to induce differentiation, cell cycle arrest, apoptosis, autophagy and necrosis in a variety of transformed cell lines. In this review, we mainly discuss how HDACi may elicit a therapeutic response to human cancers through different cell death pathways, in particular, apoptosis and autophagy.

KW - Apoptosis

KW - Autophagy

KW - Cell death

KW - Histone deacetylase inhibitor (HDACi)

KW - Histone deacetylases (HDACs)

UR - http://www.scopus.com/inward/record.url?scp=84910019636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84910019636&partnerID=8YFLogxK

U2 - 10.1007/s00018-014-1656-6

DO - 10.1007/s00018-014-1656-6

M3 - Review article

C2 - 24898083

AN - SCOPUS:84910019636

VL - 71

SP - 3885

EP - 3901

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 20

ER -