Histone-modifying enzymes: Regulators of developmental decisions and drivers of human disease

Jill S. Butler; Evangelia Koutelou; Andria C. Schibler; Sharon Y.R. Dent

doi:10.2217/epi.12.3

Histone-modifying enzymes: Regulators of developmental decisions and drivers of human disease

Jill S. Butler, Evangelia Koutelou, Andria C. Schibler, Sharon Y.R. Dent

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

Abstract

Precise transcriptional networks drive the orchestration and execution of complex developmental processes. Transcription factors possessing sequence-specific DNA binding properties activate or repress target genes in a step-wise manner to control most cell lineage decisions. This regulation often requires the interaction between transcription factors and subunits of massive protein complexes that bear enzymatic activities towards histones. The functional coupling of transcription proteins and histone modifiers underscores the importance of transcriptional regulation through chromatin modification in developmental cell fate decisions and in disease pathogenesis.

Original language	English (US)
Pages (from-to)	163-177
Number of pages	15
Journal	Epigenomics
Volume	4
Issue number	2
DOIs	https://doi.org/10.2217/epi.12.3
State	Published - Apr 2012
Externally published	Yes

Keywords

cancer
chromatin
development
differentiation
histone modifications
next-generation sequencing
pluripotency

ASJC Scopus subject areas

Genetics
Cancer Research

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10.2217/epi.12.3

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abstract = "Precise transcriptional networks drive the orchestration and execution of complex developmental processes. Transcription factors possessing sequence-specific DNA binding properties activate or repress target genes in a step-wise manner to control most cell lineage decisions. This regulation often requires the interaction between transcription factors and subunits of massive protein complexes that bear enzymatic activities towards histones. The functional coupling of transcription proteins and histone modifiers underscores the importance of transcriptional regulation through chromatin modification in developmental cell fate decisions and in disease pathogenesis.",

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AU - Dent, Sharon Y.R.

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AB - Precise transcriptional networks drive the orchestration and execution of complex developmental processes. Transcription factors possessing sequence-specific DNA binding properties activate or repress target genes in a step-wise manner to control most cell lineage decisions. This regulation often requires the interaction between transcription factors and subunits of massive protein complexes that bear enzymatic activities towards histones. The functional coupling of transcription proteins and histone modifiers underscores the importance of transcriptional regulation through chromatin modification in developmental cell fate decisions and in disease pathogenesis.

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KW - chromatin

KW - development

KW - differentiation

KW - histone modifications

KW - next-generation sequencing

KW - pluripotency

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Histone-modifying enzymes: Regulators of developmental decisions and drivers of human disease

Abstract

Keywords

ASJC Scopus subject areas

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