Histone-modifying enzymes: Regulators of developmental decisions and drivers of human disease

Jill S. Butler, Evangelia Koutelou, Andria C. Schibler, Sharon Y.R. Dent

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations

Abstract

Precise transcriptional networks drive the orchestration and execution of complex developmental processes. Transcription factors possessing sequence-specific DNA binding properties activate or repress target genes in a step-wise manner to control most cell lineage decisions. This regulation often requires the interaction between transcription factors and subunits of massive protein complexes that bear enzymatic activities towards histones. The functional coupling of transcription proteins and histone modifiers underscores the importance of transcriptional regulation through chromatin modification in developmental cell fate decisions and in disease pathogenesis.

Original languageEnglish (US)
Pages (from-to)163-177
Number of pages15
JournalEpigenomics
Volume4
Issue number2
DOIs
StatePublished - Apr 2012
Externally publishedYes

Keywords

  • cancer
  • chromatin
  • development
  • differentiation
  • histone modifications
  • next-generation sequencing
  • pluripotency

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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