Histone phosphorylation during liver regeneration

William T. Garrard, George H. Kidd, James Bonner

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12 Scopus citations

Abstract

The pattern of histone phosphorylation at acid-stable, alkali-labile sites has been examined throughout the early stages of liver regeneration, namely at times of "gene activation". Among the histones, only H1 shows an increase in phosphorylation. This increase initiates near the end of the period of chromatin template activation. Thus, there is no obvious temporal correlation between increased histone phosphorylation and increased RNA synthesis. The relative levels of phosphorylation of the various histones and the change in H1 phosphorylation observed in the liver system closely parallel the patterns exhibited by cultured animal cells during the G1 and S phases of the cycle as described by other investigators.

Original languageEnglish (US)
Pages (from-to)1219-1224
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume70
Issue number4
DOIs
StatePublished - Jun 21 1976

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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