Histopathologic diagnosis of eosinophilic conditions in the gastrointestinal tract

Jennifer M. Hurrell, Robert M. Genta, Shelby D. Melton

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

Eosinophils, a constitutive component of the columnar-lined gastrointestinal tract, play an essential role in allergic responses and parasitic infections. The tissue density of these cells also increases in a variety of conditions of uncertain etiology. With the exception of the esophageal squamous epithelium, in which no eosinophils are normally present, the population of normal eosinophils in the remainder of the luminal gut is poorly defined. Therefore, histopathologists must rely on their subjective judgment to determine when a diagnosis of eosinophilic gastritis, enteritis, or colitis should be rendered. Eosinophilic esophagitis is currently the best defined and most studied eosinophilic condition of the digestive tract; therefore, the confidence in accurate diagnosis is increasing. In contrast, the characteristic clinicopathologic features of eosinophilic conditions affecting other parts of the digestive tract remain somewhat elusive. This review was designed to present pathologists with simple and practical information for the biopsy-based histopathologic diagnosis of eosinophilic esophagitis, gastritis, enteritis, and colitis. It was prepared by critically reviewing more than 200 articles on the topic, along with incorporating evidence accumulated through our own collective experience. We anticipate that by increasing pathologists confidence in reporting these abnormal but often nameless eosinophilic infiltrates, we can help better define and characterize their significance.

Original languageEnglish (US)
Pages (from-to)335-348
Number of pages14
JournalAdvances in anatomic pathology
Volume18
Issue number5
DOIs
StatePublished - Sep 1 2011

Keywords

  • enteritis
  • eosinophilic
  • eosinophilic colitis
  • eosinophilic esophagitis
  • eosinophilic gastritis
  • eosinophilic gastroenteritis
  • eosinophils
  • gastrointestinal pathology
  • intestinal parasites

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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